| Gene Symbol |
SLC5A7
|
| Entrez Gene |
60482
|
| Alt Symbol |
CHT, CHT1, HMN7A, hCHT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 5 (sodium/choline cotransporter), member 7
|
| Other Description |
hemicholinium-3-sensitive choline transporter|high affinity choline transporter 1|high affinity choline transporter; hemicholinium-3-sensitive choline transporter|solute carrier family 5 (choline transporter), member 7|solute carrier family 5 member 7
|
| Swissprots |
Q53TF2 Q9GZV3
|
| Accessions |
AAY14927 CAC88115 EAW53893 Q9GZV3 AB043997 BAB18161 AB084377 AF276871 AAG25940 AJ401466 CAC03717 AK300801 BAG62459 AK315280 BAG37689 BC111524 AAI11525 BC111525 AAI11526 DA714970 XM_011511579 XP_011509881 XM_011511580 XP_011509882 XM_011511581 XP_011509883 NM_001305005 NP_001291934 NM_001305006 NP_001291935 NM_001305007 NP_001291936 NM_021815 NP_068587
|
| Function |
Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent. {ECO:0000269|PubMed:11027560}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:11027560}; Multi-pass membrane protein {ECO:0000269|PubMed:11027560}.
|
| Tissue Specificity |
Expressed in putamen, spinal cord and medulla. Specific for cholinergic neurons.
|
| Top Pathways |
Choline metabolism in cancer
|
![Western Blot: CHT1 Overexpression Lysate (Adult Normal) [NBL1-16176] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CHT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6562_CHT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16176-img0002.jpg)