Gene Symbol | SLC5A7 |
---|---|
Entrez Gene | 60482 |
Alt Symbol | CHT, CHT1, HMN7A, hCHT |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 5 (sodium/choline cotransporter), member 7 |
Other Description | hemicholinium-3-sensitive choline transporter|high affinity choline transporter 1|high affinity choline transporter; hemicholinium-3-sensitive choline transporter|solute carrier family 5 (choline transporter), member 7|solute carrier family 5 member 7 |
Swissprots | Q53TF2 Q9GZV3 |
Accessions | AAY14927 CAC88115 EAW53893 Q9GZV3 AB043997 BAB18161 AB084377 AF276871 AAG25940 AJ401466 CAC03717 AK300801 BAG62459 AK315280 BAG37689 BC111524 AAI11525 BC111525 AAI11526 DA714970 XM_011511579 XP_011509881 XM_011511580 XP_011509882 XM_011511581 XP_011509883 NM_001305005 NP_001291934 NM_001305006 NP_001291935 NM_001305007 NP_001291936 NM_021815 NP_068587 |
Function | Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent. {ECO:0000269|PubMed:11027560}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11027560}; Multi-pass membrane protein {ECO:0000269|PubMed:11027560}. |
Tissue Specificity | Expressed in putamen, spinal cord and medulla. Specific for cholinergic neurons. |
Top Pathways | Choline metabolism in cancer |
CHT1 CRISPR/Cas9 KO Plasmid (h) - sc-404869 from Santa Cruz Biotechnology
|
||||||||
CHT1 HDR Plasmid (h) - sc-404869-HDR from Santa Cruz Biotechnology
|
||||||||
CHT1 Double Nickase Plasmid (h) - sc-404869-NIC from Santa Cruz Biotechnology
|
||||||||
CHT1 Double Nickase Plasmid (h2) - sc-404869-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CHT1 CRISPR Activation Plasmid (h) - sc-404869-ACT from Santa Cruz Biotechnology
|
||||||||
CHT1 CRISPR Activation Plasmid (h2) - sc-404869-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CHT1 Lentiviral Activation Particles (h) - sc-404869-LAC from Santa Cruz Biotechnology
|
||||||||
CHT1 Lentiviral Activation Particles (h2) - sc-404869-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CHT1 siRNA (h) - sc-44594 from Santa Cruz Biotechnology
|
||||||||
CHT1 shRNA Plasmid (h) - sc-44594-SH from Santa Cruz Biotechnology
|
||||||||
CHT1 shRNA (h) Lentiviral Particles - sc-44594-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU000431 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19667 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19667 from Sigma-Aldrich
|
||||||||
SLC5A7 siRNA (Human) - CRJ1797 from Cohesion Biosciences
|
||||||||
CHT1 RNAi - H00060482-R01 from Novus Biologicals
|
||||||||
SLC5A7 - MBS8237517 from MyBioSource
|
||||||||
shRNA set against Human SLC5A7 (NM_021815.2) - SHH411764 from Creative biogene
|
||||||||
shRNA set against Human SLC5A7(NM_021815.2) - SHL010774 from Creative biogene
|
||||||||
Human SLC5A7 siRNA - orb272298 from Biorbyt
|
||||||||
SLC5A7 shRNA Plasmid (Human) - CHJ1797 from Cohesion Biosciences
|
||||||||
SLC5A7 miRNA 3'UTR clone - MiUTR1H-09588 from Creative biogene
|