Gene Symbol | SLC5A7 |
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Entrez Gene | 60482 |
Alt Symbol | CHT, CHT1, HMN7A, hCHT |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 5 (sodium/choline cotransporter), member 7 |
Other Description | hemicholinium-3-sensitive choline transporter|high affinity choline transporter 1|high affinity choline transporter; hemicholinium-3-sensitive choline transporter|solute carrier family 5 (choline transporter), member 7|solute carrier family 5 member 7 |
Swissprots | Q53TF2 Q9GZV3 |
Accessions | AAY14927 CAC88115 EAW53893 Q9GZV3 AB043997 BAB18161 AB084377 AF276871 AAG25940 AJ401466 CAC03717 AK300801 BAG62459 AK315280 BAG37689 BC111524 AAI11525 BC111525 AAI11526 DA714970 XM_011511579 XP_011509881 XM_011511580 XP_011509882 XM_011511581 XP_011509883 NM_001305005 NP_001291934 NM_001305006 NP_001291935 NM_001305007 NP_001291936 NM_021815 NP_068587 |
Function | Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent. {ECO:0000269|PubMed:11027560}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11027560}; Multi-pass membrane protein {ECO:0000269|PubMed:11027560}. |
Tissue Specificity | Expressed in putamen, spinal cord and medulla. Specific for cholinergic neurons. |
Top Pathways | Choline metabolism in cancer |
CHT1 (62-2ES) - sc-33713 from Santa Cruz Biotechnology
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CHT1 (N-17) - sc-27517 from Santa Cruz Biotechnology
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CHT1 (CT1) - sc-52520 from Santa Cruz Biotechnology
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CHT1 (5K101) - sc-70859 from Santa Cruz Biotechnology
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Anti-SLC5A7 antibody - ab135043 from Abcam
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Anti-SLC5A7 antibody - ab56074 from Abcam
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Anti-SLC5A7 / Choline Transporter Antibody (C-Terminus) - LS-C46817 from LifeSpan Bioscience
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Anti-Slc5a7 / Choline Transporter Antibody (clone 62-2E8) - LS-C180184 from LifeSpan Bioscience
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Anti-SLC5A7 / Choline Transporter Antibody (aa468-517) - LS-C110848 from LifeSpan Bioscience
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Anti-SLC5A7 / Choline Transporter Antibody (C-Terminus) - LS-C152949 from LifeSpan Bioscience
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Anti-SLC5A7 / Choline Transporter Antibody (C-Terminus) - LS-C201463 from LifeSpan Bioscience
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Anti-SLC5A7 / Choline Transporter Antibody (C-Terminus, clone 62-2E8) - LS-C141775 from LifeSpan Bioscience
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CHT1 Antibody (62-2E8) - NB110-74570 from Novus Biologicals
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CHT1 Antibody - NBP1-62339 from Novus Biologicals
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Anti-SLC5A7 antibody produced in rabbit - HPA046105 from Sigma-Aldrich
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Anti-SLC5A7 antibody produced in rabbit - SAB2102221 from Sigma-Aldrich
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SLC5A7 antibody - middle region (ARP44024_P050) - ARP44024_P050 from Aviva Systems Biology
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SLC5A7 Antibody - C-terminal region (ARP44025_P050) - ARP44025_P050 from Aviva Systems Biology
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SLC5A7 antibody - orb67028 from Biorbyt
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SLC5A7 antibody - 70R-7211 from Fitzgerald
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SLC5A7 / CHT1 antibody - 21848-1-AP from Acris Antibodies
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SLC5A7 / CHT1 (C-term) antibody - AM32622SU-N from Acris Antibodies
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SLC5A7 / CHT1 antibody - MAB2295 from Acris Antibodies
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SLC5A7 / CHT1 antibody - PAB5294 from Acris Antibodies
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CHT1 antibody - 21848-1-AP from Proteintech Group
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