| Gene Symbol | SLC27A2 |
|---|---|
| Entrez Gene | 11001 |
| Alt Symbol | ACSVL1, FACVL1, FATP2, HsT17226, VLACS, VLCS, hFACVL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 27 (fatty acid transporter), member 2 |
| Other Description | FATP-2|THCA-CoA ligase|fatty acid transport protein 2|fatty-acid-coenzyme A ligase, very long-chain 1|long-chain-fatty-acid--CoA ligase|solute carrier family 27 member 2|very long-chain acyl-CoA synthetase|very long-chain fatty-acid-coenzyme A ligase 1|very long-chain-fatty-acid-CoA ligase|very-long-chain acyl-CoA synthetase |
| Swissprots | O14975 Q6PF09 Q53FY6 A8K2J7 |
| Accessions | EAW77384 EAW77385 EAW77386 O14975 AF096290 AAC64973 AK123905 BAG53981 AK222859 BAD96579 AK223145 BAD96865 AK290262 BAF82951 BC057770 AAH57770 BM980042 D88308 BAA23644 NM_001159629 NP_001153101 NM_003645 NP_003636 |
| Function | Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes. |
| Tissue Specificity | Expressed in liver, kidney, placenta and pancreas. {ECO:0000269|PubMed:10198260}. |
| Top Pathways | PPAR signaling pathway, Peroxisome |