Gene Symbol | SLC27A2 |
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Entrez Gene | 11001 |
Alt Symbol | ACSVL1, FACVL1, FATP2, HsT17226, VLACS, VLCS, hFACVL1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 27 (fatty acid transporter), member 2 |
Other Description | FATP-2|THCA-CoA ligase|fatty acid transport protein 2|fatty-acid-coenzyme A ligase, very long-chain 1|long-chain-fatty-acid--CoA ligase|solute carrier family 27 member 2|very long-chain acyl-CoA synthetase|very long-chain fatty-acid-coenzyme A ligase 1|very long-chain-fatty-acid-CoA ligase|very-long-chain acyl-CoA synthetase |
Swissprots | O14975 Q6PF09 Q53FY6 A8K2J7 |
Accessions | EAW77384 EAW77385 EAW77386 O14975 AF096290 AAC64973 AK123905 BAG53981 AK222859 BAD96579 AK223145 BAD96865 AK290262 BAF82951 BC057770 AAH57770 BM980042 D88308 BAA23644 NM_001159629 NP_001153101 NM_003645 NP_003636 |
Function | Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes. |
Tissue Specificity | Expressed in liver, kidney, placenta and pancreas. {ECO:0000269|PubMed:10198260}. |
Top Pathways | PPAR signaling pathway, Peroxisome |
Human FATP2 full length protein - ab161235 from Abcam
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Human FATP2 peptide - ab96629 from Abcam
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Human FATP2 protein fragment - ab161236 from Abcam
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FATP2/SLC27A2 Partial Recombinant Protein - H00011001-Q01 from Novus Biologicals
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Recombinant Human FATP2/SLC27A2 Protein - H00011001-P01 from Novus Biologicals
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Human SLC27A2 protein - orb245993 from Biorbyt
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Human SLC27A2 protein - orb246437 from Biorbyt
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SLC27A2 Blocking Peptide - 33R-5137 from Fitzgerald
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SLC27A2 / FATP2 - H00011001-P01 from Acris Antibodies
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SLC27A2 / FATP2 - H00011001-Q01 from Acris Antibodies
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SLC27A2 fusion protein - ag5217 from Proteintech Group
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SLC27A2 fusion protein - Ag5390 from Proteintech Group
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Recombinant human Very long-chain acyl-CoA synthetase - CSB-EP021534HU CSB-BP021534HU CSB-MP021534HU from Cusabio
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Recombinant Human Very long-chain acyl-CoA synthetase(SLC27A2) - CSB-YP021534HU CSB-BP021534HU CSB-MP021534HU from Cusabio
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Recombinant Human Very long-chain acyl-CoA synthetase(SLC27A2) - CSB-EP021534HU from Cusabio
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SLC27A2 / FATP2 - TP321033 from Acris Antibodies
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Very long-chain acyl-CoA synthetase (SLC27A2), Recombinant Protein - MBS1032322 from MyBioSource
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SLC27A2 Peptide, Human - M34GP14466H from Creative Peptides
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SLC27A2 Recombinant Protein (OPCA01858) - OPCA01858 from Aviva Systems Biology
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SLC27A2 Recombinant Protein (OPCA02795) - OPCA02795 from Aviva Systems Biology
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Recombinant human Very long-chain acyl-CoA synthetase - AP70781 from Signalway Antibody
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Recombinant human Very long-chain acyl-CoA synthetase - AP72785 from Signalway Antibody
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Long-chain-fatty-acid--CoA ligase, Recombinant Protein - MBS9420828 from MyBioSource
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Long-chain-fatty-acid--CoA ligase, Recombinant Protein - MBS1263736 from MyBioSource
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Recombinant Human SLC27A2 Protein (283-620 aa), His-tagged - SLC27A2-1521H from Creative Biomart
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