| Gene Symbol |
CPSF4
|
| Entrez Gene |
10898
|
| Alt Symbol |
CPSF30, NAR, NEB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cleavage and polyadenylation specific factor 4, 30kDa
|
| Other Description |
CPSF 30 kDa subunit|NS1 effector domain-binding protein 1|cleavage and polyadenylation specificity factor 30 kDa subunit|cleavage and polyadenylation specificity factor subunit 4|cleavage-polyadenylation specificity factor, 30kD|neb-1|no arches homolog|no arches-like zinc finger protein
|
| Swissprots |
Q86TF8 O95639 Q6FGE6 D6W5S8 Q9BTW6
|
| Accessions |
ABN05292 EAL23878 EAW76662 EAW76663 EAW76664 EAW76665 EAW76666 EAW76667 EAW76668 O95639 AA040394 AI076832 AK301745 BAH13546 BC003101 AAH03101 BC050738 AAH50738 BM757197 BM787372 BQ052009 BQ641871 CR542161 CAG46958 CX754488 HQ448622 ADQ33100 U79569 AAD00321 XM_011515755 XP_011514057 XM_011515756 XP_011514058 XM_011515757 XP_011514059 XM_011515758 XP_011514060 XM_011515759 XP_011514061 NM_001081559 NP_001075028 NM_006693 NP_006684
|
| Function |
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:9224719}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
mRNA surveillance pathway, Influenza A
|