Gene Symbol | CPSF4 |
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Entrez Gene | 10898 |
Alt Symbol | CPSF30, NAR, NEB1 |
Species | Human |
Gene Type | protein-coding |
Description | cleavage and polyadenylation specific factor 4, 30kDa |
Other Description | CPSF 30 kDa subunit|NS1 effector domain-binding protein 1|cleavage and polyadenylation specificity factor 30 kDa subunit|cleavage and polyadenylation specificity factor subunit 4|cleavage-polyadenylation specificity factor, 30kD|neb-1|no arches homolog|no arches-like zinc finger protein |
Swissprots | Q86TF8 O95639 Q6FGE6 D6W5S8 Q9BTW6 |
Accessions | ABN05292 EAL23878 EAW76662 EAW76663 EAW76664 EAW76665 EAW76666 EAW76667 EAW76668 O95639 AA040394 AI076832 AK301745 BAH13546 BC003101 AAH03101 BC050738 AAH50738 BM757197 BM787372 BQ052009 BQ641871 CR542161 CAG46958 CX754488 HQ448622 ADQ33100 U79569 AAD00321 XM_011515755 XP_011514057 XM_011515756 XP_011514058 XM_011515757 XP_011514059 XM_011515758 XP_011514060 XM_011515759 XP_011514061 NM_001081559 NP_001075028 NM_006693 NP_006684 |
Function | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:9224719}. |
Subcellular Location | Nucleus. |
Top Pathways | mRNA surveillance pathway, Influenza A |
CPSF4 CRISPR/Cas9 KO Plasmid (h) - sc-403190 from Santa Cruz Biotechnology
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CPSF4 HDR Plasmid (h) - sc-403190-HDR from Santa Cruz Biotechnology
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CPSF4 Double Nickase Plasmid (h) - sc-403190-NIC from Santa Cruz Biotechnology
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CPSF4 Double Nickase Plasmid (h2) - sc-403190-NIC-2 from Santa Cruz Biotechnology
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CPSF4 CRISPR Activation Plasmid (h) - sc-403190-ACT from Santa Cruz Biotechnology
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CPSF4 CRISPR Activation Plasmid (h2) - sc-403190-ACT-2 from Santa Cruz Biotechnology
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CPSF4 Lentiviral Activation Particles (h) - sc-403190-LAC from Santa Cruz Biotechnology
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CPSF4 Lentiviral Activation Particles (h2) - sc-403190-LAC-2 from Santa Cruz Biotechnology
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CPSF4 siRNA (h) - sc-72988 from Santa Cruz Biotechnology
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CPSF4 shRNA Plasmid (h) - sc-72988-SH from Santa Cruz Biotechnology
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CPSF4 shRNA (h) Lentiviral Particles - sc-72988-V from Santa Cruz Biotechnology
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CPSF4 RNAi - H00010898-R01 from Novus Biologicals
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MISSION® esiRNA - EHU132701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6526 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6526 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12374 from Sigma-Aldrich
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CPSF4 siRNA (Human) - CRH7427 from Cohesion Biosciences
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CPSF4 - MBS8216539 from MyBioSource
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CPSF4 CRISPR/Cas9 KO Plasmid (h2) - sc-403190-KO-2 from Santa Cruz Biotechnology
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CPSF4 HDR Plasmid (h2) - sc-403190-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CPSF4 (NM_006693.2) - SHH268957 from Creative biogene
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shRNA set against Human CPSF4(NM_006693.2) - SHG170803 from Creative biogene
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shRNA set against Human CPSF4(NM_001081559.1) - SHG170845 from Creative biogene
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CPSF4 shRNA Plasmid (Human) - CHH7427 from Cohesion Biosciences
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CPSF4 miRNA 3'UTR clone - MiUTR1H-02399 from Creative biogene
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