Gene Symbol | LARP1 |
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Entrez Gene | 23367 |
Alt Symbol | LARP |
Species | Human |
Gene Type | protein-coding |
Description | La ribonucleoprotein domain family, member 1 |
Other Description | la-related protein 1 |
Swissprots | Q8N4M2 Q9UFD7 O94836 Q6PKG0 Q8NB73 |
Accessions | EAW61632 EAW61633 EAW61634 Q6PKG0 AB018274 BAA34451 AK091465 BAC03668 AK307554 AK312203 BAG35136 AL133034 CAB61364 BC001460 AAH01460 BC003063 BC010144 BC015573 BC033856 AAH33856 BC038220 BQ003824 BQ422667 EU446783 ABZ92312 JF432319 ADZ15536 XM_005268404 XP_005268461 XM_005268406 XP_005268463 XM_005268407 XP_005268464 XM_005268408 XP_005268465 XM_006714775 XP_006714838 XM_006714776 XP_006714839 XM_011537614 XP_011535916 XM_011537615 XP_011535917 XM_011537616 XP_011535918 XM_011537617 XP_011535919 XM_011537618 XP_011535920 NM_033551 NM_015315 NP_056130 |
Function | RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:24532714}. |
LARP1 Antibody - 14763 from Cell Signaling Technology
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LARP1 (H-72) - sc-292833 from Santa Cruz Biotechnology
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LARP1 (S-14) - sc-131975 from Santa Cruz Biotechnology
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LARP1 (P-12) - sc-131974 from Santa Cruz Biotechnology
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LARP1 (P-21) - sc-102006 from Santa Cruz Biotechnology
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Anti-LARP1 antibody - ab86359 from Abcam
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Anti-LARP1 antibody - ab101490 from Abcam
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Anti-LARP1 antibody - C-terminal - ab176602 from Abcam
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Anti-LARP1 / La-Related Protein 1 Antibody (aa107-156) - LS-C107499 from LifeSpan Bioscience
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Anti-LARP1 / La-Related Protein 1 Antibody (aa36-85) - LS-C82434 from LifeSpan Bioscience
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Anti-LARP1 / La-Related Protein 1 Antibody (N-Terminus) - LS-C116910 from LifeSpan Bioscience
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Anti-LARP1 / La-Related Protein 1 Antibody - LS-C308713 from LifeSpan Bioscience
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Anti-LARP1 / La-Related Protein 1 Antibody (aa575-625) - LS-C286772 from LifeSpan Bioscience
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Anti-LARP1 / La-Related Protein 1 Antibody (aa575-625) - LS-C288843 from LifeSpan Bioscience
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Anti-LARP1 / La-Related Protein 1 Antibody (aa275-325) - LS-C288842 from LifeSpan Bioscience
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LARP1 Antibody - NBP1-19128 from Novus Biologicals
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LARP1 Antibody - NBP1-19129 from Novus Biologicals
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LARP1 Antibody - H00023367-B01P from Novus Biologicals
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Anti-LARP1, (N-terminal) antibody produced in rabbit - SAB2104703 from Sigma-Aldrich
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Anti-LARP1 antibody produced in rabbit - AV41075 from Sigma-Aldrich
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Anti-LARP1 antibody produced in mouse - SAB1407205 from Sigma-Aldrich
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Anti-LARP2 antibody produced in rabbit - AV34532 from Sigma-Aldrich
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LARP2 antibody - middle region (ARP34532_T100) - ARP34532_T100 from Aviva Systems Biology
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LARP1 antibody - N-terminal region (ARP41075_P050) - ARP41075_P050 from Aviva Systems Biology
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LARP1 antibody - N-terminal region (ARP41076_P050) - ARP41076_P050 from Aviva Systems Biology
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