| Gene Symbol |
LARP1
|
| Entrez Gene |
23367
|
| Alt Symbol |
LARP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
La ribonucleoprotein domain family, member 1
|
| Other Description |
la-related protein 1
|
| Swissprots |
Q8N4M2 Q9UFD7 O94836 Q6PKG0 Q8NB73
|
| Accessions |
EAW61632 EAW61633 EAW61634 Q6PKG0 AB018274 BAA34451 AK091465 BAC03668 AK307554 AK312203 BAG35136 AL133034 CAB61364 BC001460 AAH01460 BC003063 BC010144 BC015573 BC033856 AAH33856 BC038220 BQ003824 BQ422667 EU446783 ABZ92312 JF432319 ADZ15536 XM_005268404 XP_005268461 XM_005268406 XP_005268463 XM_005268407 XP_005268464 XM_005268408 XP_005268465 XM_006714775 XP_006714838 XM_006714776 XP_006714839 XM_011537614 XP_011535916 XM_011537615 XP_011535917 XM_011537616 XP_011535918 XM_011537617 XP_011535919 XM_011537618 XP_011535920 NM_033551 NM_015315 NP_056130
|
| Function |
RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery. Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation. {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:23711370, ECO:0000269|PubMed:24532714}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:24532714}.
|