Gene Symbol | ERAP2 |
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Entrez Gene | 64167 |
Alt Symbol | L-RAP, LRAP |
Species | Human |
Gene Type | protein-coding |
Description | endoplasmic reticulum aminopeptidase 2 |
Other Description | leukocyte-derived arginine aminopeptidase |
Swissprots | Q8TD32 Q6P179 Q9HBX2 Q8WVJ4 Q7Z5K1 |
Accessions | EAW96080 EAW96081 EAW96082 Q6P179 AB109031 BAC78818 AB163917 BAD90015 AF191545 AAG28383 AK074213 AK074281 AK074387 AK312864 BAG35716 AV688559 AY028805 AAK37776 BC017927 AAH17927 BC065240 AAH65240 BU430967 DA990479 DB159802 XM_011543544 XP_011541846 XR_948283 NM_001130140 NP_001123612 NM_022350 NP_071745 |
Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12799365}; Single-pass type II membrane protein {ECO:0000269|PubMed:12799365}. |
Tissue Specificity | Ubiquitously expressed. Highly expressed in spleen and leukocytes. {ECO:0000269|PubMed:12799365}. |
ERAP2 (S-13) - sc-161039 from Santa Cruz Biotechnology
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Anti-ERAP2 antibody - ab69037 from Abcam
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Anti-ERAP2 antibody - ab82142 from Abcam
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Anti-ERAP2 antibody - N-terminal - ab181404 from Abcam
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Anti-ERAP2 / Aminopeptidase Antibody - LS-C309188 from LifeSpan Bioscience
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Anti-ERAP2 / Aminopeptidase Antibody (aa480-493) - LS-C87287 from LifeSpan Bioscience
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Anti-ERAP2 / Aminopeptidase Antibody (N-Terminus) IHC-plus⢠- LS-B10127 from LifeSpan Bioscience
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Aminopeptidase LRAP/ERAP2 Antibody - AF3830 from Novus Biologicals
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Aminopeptidase LRAP/ERAP2 Antibody (3F5) - MAB3830 from Novus Biologicals
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Aminopeptidase LRAP/ERAP2 Antibody - NBP2-37872 from Novus Biologicals
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Aminopeptidase LRAP/ERAP2 Antibody - H00064167-B01P from Novus Biologicals
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Aminopeptidase LRAP/ERAP2 Antibody - NBP1-20913 from Novus Biologicals
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Aminopeptidase LRAP/ERAP2 Antibody [Biotin] - BAF3830 from Novus Biologicals
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Anti-LRAP antibody produced in mouse - SAB1400672 from Sigma-Aldrich
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Anti-ERAP2 antibody produced in goat - SAB2500360 from Sigma-Aldrich
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Anti-ERAP2 antibody produced in rabbit - SAB3500959 from Sigma-Aldrich
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ERAP2-Antibody - AF1375a from Abgent, a WuXi AppTec company
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ERAP2 antibody, Internal - GTX88698 from GeneTex
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Human Aminopeptidase LRAP/ERAP2 Antibody - MAB3830 from R&D Systems
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Human Aminopeptidase LRAP/ERAP2 MAb (Clone 3F5), Mouse IgG1 - MAB3830-SP from R&D Systems
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Human Aminopeptidase LRAP/ERAP2 Biotinylated Antibody - BAF3830 from R&D Systems
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Human Aminopeptidase LRAP/ERAP2 Antibody - AF3830 from R&D Systems
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Human Aminopeptidase LRAP/ERAP2 Affinity Purified PAb, Goat IgG - AF3830-SP from R&D Systems
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ERAP2 Antibody (OAEB01437) - OAEB01437 from Aviva Systems Biology
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Anti -ERAP2 (Endoplasmic Reticulum Aminopeptidase 2, Leukocyte-derived ArginineAminopeptidase, L-RAP, LRAP) - E2291-58 from USBiological Life Science
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