ERAP2

Gene Symbol ERAP2
Entrez Gene 64167
Alt Symbol L-RAP, LRAP
Species Human
Gene Type protein-coding
Description endoplasmic reticulum aminopeptidase 2
Other Description leukocyte-derived arginine aminopeptidase
Swissprots Q8TD32 Q6P179 Q9HBX2 Q8WVJ4 Q7Z5K1
Accessions EAW96080 EAW96081 EAW96082 Q6P179 AB109031 BAC78818 AB163917 BAD90015 AF191545 AAG28383 AK074213 AK074281 AK074387 AK312864 BAG35716 AV688559 AY028805 AAK37776 BC017927 AAH17927 BC065240 AAH65240 BU430967 DA990479 DB159802 XM_011543544 XP_011541846 XR_948283 NM_001130140 NP_001123612 NM_022350 NP_071745
Function Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12799365}; Single-pass type II membrane protein {ECO:0000269|PubMed:12799365}.
Tissue Specificity Ubiquitously expressed. Highly expressed in spleen and leukocytes. {ECO:0000269|PubMed:12799365}.

Human ERAP2 cDNA clone(NM_001130140.1) - CDFH006038 from Creative Biomart

Species Human
Accession NM_001130140.1

Human ERAP2 ORF Clone(NM_001130140.1) - CDCL162536 from Creative Biomart

Species Human
Accession NM_001130140.1

Human ERAP2 ORF Clone(NM_001130140.1) - CDCL162537 from Creative Biomart

Species Human
Accession NM_001130140.1

Human ERAP2 ORF Clone(NM_001130140.1) - CDCR349329 from Creative Biomart

Species Human
Accession NM_001130140.1

Human ERAP2 ORF Clone(NM_001130140.1) - CDCR349330 from Creative Biomart

Species Human
Accession NM_001130140.1

Human LRAP ORF clone(NM_022350.3) - CDCL185187 from Creative biogene

Species Human

Human ERAP2 ORF Clone(NM_001130140.1) - CDCR349329 from Creative biogene

Species Human

Human ERAP2 cDNA Clone(NM_001130140.1) - CDFH006038 from Creative biogene

Species Human
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