Gene Symbol | ERAP2 |
---|---|
Entrez Gene | 64167 |
Alt Symbol | L-RAP, LRAP |
Species | Human |
Gene Type | protein-coding |
Description | endoplasmic reticulum aminopeptidase 2 |
Other Description | leukocyte-derived arginine aminopeptidase |
Swissprots | Q8TD32 Q6P179 Q9HBX2 Q8WVJ4 Q7Z5K1 |
Accessions | EAW96080 EAW96081 EAW96082 Q6P179 AB109031 BAC78818 AB163917 BAD90015 AF191545 AAG28383 AK074213 AK074281 AK074387 AK312864 BAG35716 AV688559 AY028805 AAK37776 BC017927 AAH17927 BC065240 AAH65240 BU430967 DA990479 DB159802 XM_011543544 XP_011541846 XR_948283 NM_001130140 NP_001123612 NM_022350 NP_071745 |
Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12799365}; Single-pass type II membrane protein {ECO:0000269|PubMed:12799365}. |
Tissue Specificity | Ubiquitously expressed. Highly expressed in spleen and leukocytes. {ECO:0000269|PubMed:12799365}. |