Gene Symbol | ERAP2 |
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Entrez Gene | 64167 |
Alt Symbol | L-RAP, LRAP |
Species | Human |
Gene Type | protein-coding |
Description | endoplasmic reticulum aminopeptidase 2 |
Other Description | leukocyte-derived arginine aminopeptidase |
Swissprots | Q8TD32 Q6P179 Q9HBX2 Q8WVJ4 Q7Z5K1 |
Accessions | EAW96080 EAW96081 EAW96082 Q6P179 AB109031 BAC78818 AB163917 BAD90015 AF191545 AAG28383 AK074213 AK074281 AK074387 AK312864 BAG35716 AV688559 AY028805 AAK37776 BC017927 AAH17927 BC065240 AAH65240 BU430967 DA990479 DB159802 XM_011543544 XP_011541846 XR_948283 NM_001130140 NP_001123612 NM_022350 NP_071745 |
Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12799365}; Single-pass type II membrane protein {ECO:0000269|PubMed:12799365}. |
Tissue Specificity | Ubiquitously expressed. Highly expressed in spleen and leukocytes. {ECO:0000269|PubMed:12799365}. |
Human ERAP2 full length protein - ab163795 from Abcam
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ERAP2 / Aminopeptidase Antibody Blocking Peptide - LS-E26737 from LifeSpan Bioscience
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Recombinant Human Aminopeptidase LRAP/ERAP2 Protein - H00064167-P01 from Novus Biologicals
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ERAP2 blocking peptide - GTX88698-PEP from GeneTex
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Recombinant Human Aminopeptidase LRAP/ERAP2, CF - 3830-ZN-010 from R&D Systems
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Human LRAP His tag protein - orb83199 from Biorbyt
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ERAP2 Peptide - AC21-1574-P from Abcore
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ERAP2 / LRAP - H00064167-P01-10 from Acris Antibodies
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ERAP2 / LRAP - H00064167-P01-25 from Acris Antibodies
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ERAP2 Peptide - 7469P from ProSci
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ERAP2 Peptide - 46-837P from ProSci
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ERAP2 fusion protein - ag13406 from Proteintech Group
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ERAP2 fusion protein - Ag6216 from Proteintech Group
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ERAP2 fusion protein - ag6351 from Proteintech Group
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Recombinant Human ERAP2, His tagged - ERAP2-304H from Creative Biomart
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Recombinant Human ERAP2 - ERAP2-936H from Creative Biomart
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ERAP2 - PN201512 from Elabscience
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Recombinant Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) - RPG456Hu01 from Uscn Life Science Inc.
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Recombinant Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) - RPG456Hu01 from Cloud-clone
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Recombinant Human Endoplasmic reticulum aminopeptidase 2(ERAP2) ,partial - CSB-YP007761HU CSB-EP007761HU CSB-BP007761HU CSB-MP007761HU from Cusabio
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Recombinant Human Aminopeptidase LRAP/ERAP2 Protein, CF - 3830-ZN from R&D Systems
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Endoplasmic Reticulum Aminopeptidase 2 Protein (Recombinant) - abx166758 from Abbexa
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ERAP2, Peptide - MBS425890 from MyBioSource
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Human LRAP / ERAP2 Protein (His Tag) - 10734-H07H-10 from Sino Biological
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Recombinant Human LRAP / ERAP2 Protein (His tag) - PKSH031454 from Elabscience
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