| Gene Symbol |
DAZ4
|
| Entrez Gene |
57135
|
| Alt Symbol |
pDP1680, pDP1681
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
deleted in azoospermia 4
|
| Other Description |
deleted in azoospermia protein 4
|
| Swissprots |
Q86SG3 Q9NR88 Q9NR89
|
| Accessions |
CBH19254 CBH30638 Q86SG3 AA608617 AF248482 AAF91331 AF248483 AAF91332 AL833003 CAH56318 BC047480 AAH47480 BC047617 AAH47617 XM_005262602 XP_005262659 XM_011531509 XP_011529811 XM_011531510 XP_011529812 NM_001005375 NP_001005375 NM_020420 NP_065153
|
| Function |
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11058556}. Nucleus {ECO:0000269|PubMed:11058556}. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
|
| Tissue Specificity |
Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level). {ECO:0000269|PubMed:10936047, ECO:0000269|PubMed:18385127, ECO:0000269|PubMed:19223287}.
|