| Gene Symbol |
IL26
|
| Entrez Gene |
55801
|
| Alt Symbol |
AK155, IL-26
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 26
|
| Other Description |
interleukin-26
|
| Swissprots |
Q9NPH9
|
| Accessions |
AAR87776 CAB77049 EAW97181 Q9NPH9 AJ251549 CAB76942 BC066270 AAH66270 BC066271 AAH66271 HQ447556 ADQ32042 XM_011538568 XP_011536870 NM_018402 NP_060872
|
| Function |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. {ECO:0000269|PubMed:14764663, ECO:0000269|PubMed:15178681, ECO:0000269|PubMed:18483078}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:18483078}.
|
| Tissue Specificity |
Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level). {ECO:0000269|PubMed:18483078}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|
![Western Blot: IL26 Overexpression Lysate (Adult Normal) [NBP2-06805] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IL26.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4715_IL26%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06805-img0001.jpg)