RDH5

Gene Symbol RDH5
Entrez Gene 5959
Alt Symbol 9cRDH, HSD17B9, RDH1, SDR9C5
Species Human
Gene Type protein-coding
Description retinol dehydrogenase 5 (11-cis/9-cis)
Other Description 11-cis RDH|11-cis RoDH|11-cis retinol dehydrogenase|9-cis retinol dehydrogenase|9-cis-retinol specific dehydrogenase|retinol dehydrogenase 1|retinol dehydrogenase 5 (11-cis and 9-cis)|short chain dehydrogenase/reductase family 9C member 5|short chain dehydrogenase/reductase family 9C, member 5
Swissprots O00179 Q92781 Q8TAI2
Accessions AAC09250 EAW96825 EAW96826 Q92781 AK293313 BAG56833 AK307157 BC028298 AAH28298 BI765016 BP381700 BU617433 BU731044 DQ426887 HQ447382 ADQ31868 U43559 AAC50725 U89717 AAB93668 NM_001199771 NP_001186700 NM_002905 NP_002896
Function Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. {ECO:0000269|PubMed:10588954, ECO:0000269|PubMed:9115228}.
Subcellular Location Membrane {ECO:0000269|PubMed:11675386}; Peripheral membrane protein {ECO:0000269|PubMed:11675386}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:11675386}.
Tissue Specificity Abundant in the retinal pigment epithelium. Expressed at high levels in mammary tissue, kidney and testis, and at lower levels in liver, heart, adrenal gland, lung, pancreas and skeletal muscle. {ECO:0000269|PubMed:9115228}.
Top Pathways Retinol metabolism

RDH5 (G-5) - sc-377057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RDH5 (G-5): sc-377057. Western blot analysis of RDH5 expression in non-transfected: sc-117752 (A) and human RDH5 transfected: sc-158923 (B) 293T whole cell lysates.

RDH5 (H-40) - sc-98348 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RDH5 (H-40): sc-98348. Western blot analysis of RDH5 expression in non-transfected: sc-117752 (A) and human RDH5 transfected: sc-158923 (B) 293T whole cell lysates.

RDH5 (I-14) - sc-79025 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RDH5 (T-14) - sc-79026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RDH5 (T-14): sc-79026. Western blot analysis of RDH5 expression in non-transfected: sc-117752 (A) and human RDH5 transfected: sc-158923 (B) 293T whole cell lysates.

Anti-RDH5 antibody - ab106738 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab106738 (5µg/ml) staining of RDH5 in paraffin embedded Human Retina following steamed antigen retrieval with citrate buffer pH 6 and AP-staining. This shows staining of the Ganglion Cell Layer.

Anti-RDH1 / RDH5 Antibody (aa19-31) IHC-plus™ - LS-B9519 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-RDH1 / RDH5 antibody IHC staining of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9519 concentration 5 ug/ml.

Anti-RDH1 / RDH5 Antibody (aa209-221) - LS-C113005 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

RDH5 Antibody - NBP2-15097 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RDH5 Antibody [NBP2-15097] - Sample (30 ug of whole cell lysate) A: NT2D1 10% SDS PAGE; antibody diluted at 1:1000.

RDH5 Antibody - NBP1-52047 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: RDH5 Antibody [NBP1-52047] - Western blot analysis of RDH5 (aa 19-31) in Mouse Eye lysate (35ug protein in RIPA buffer) using NBP1-52047 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

RDH5 Antibody - H00005959-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

RDH5 Antibody - NBP1-49894 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-RDH5 antibody produced in goat - SAB2501462 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RDH5 <B>Cat. No. SAB2501462</B>: (2 μg/mL) staining of Mouse Eye lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-RDH5 antibody produced in rabbit - SAB2701182 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RDH5: <B>Cat. No. SAB2701182</B>: Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using RDH5 antibody at 1:500 dilution.

Anti-RDH5 (81-92) antibody produced in rabbit - SAB1100373 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-RDH5 (81-92), <B>Cat. No. SAB1100373</B>: Immunofluorescence of HUVEC cells using Anti-RDH5 (81-92), SAB1100373 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

RDH5-aa-19-31-Antibody-internal-region - AF3225a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3225a (5 µg/ml) staining of paraffin embedded Human Retina. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

RDH5-Antibody-internal-region - AF3224a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

RDH5 Antibody (OAEB00223) - OAEB00223 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

RDH5 Antibody (OAEB02216) - OAEB02216 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

RDH5 / RDH1 (19-31) antibody - AP21505PU-N from Acris Antibodies

Prices $310.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Staining of paraffin embedded Human Retina using RDH5 Antibody Cat.-No AP21505PU-N at 5 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

RDH5 / RDH1 antibody - H00005959-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-RDH5 Antibody - AC21-2207 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-RDH5 Antibody - AC21-2208 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-RDH5 Antibody (AMCA) - AC21-2207-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-RDH5 Antibody (AMCA) - AC21-2208-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-RDH5 Antibody (AP) - AC21-2207-02 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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