| Gene Symbol |
RDH5
|
| Entrez Gene |
5959
|
| Alt Symbol |
9cRDH, HSD17B9, RDH1, SDR9C5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinol dehydrogenase 5 (11-cis/9-cis)
|
| Other Description |
11-cis RDH|11-cis RoDH|11-cis retinol dehydrogenase|9-cis retinol dehydrogenase|9-cis-retinol specific dehydrogenase|retinol dehydrogenase 1|retinol dehydrogenase 5 (11-cis and 9-cis)|short chain dehydrogenase/reductase family 9C member 5|short chain dehydrogenase/reductase family 9C, member 5
|
| Swissprots |
O00179 Q92781 Q8TAI2
|
| Accessions |
AAC09250 EAW96825 EAW96826 Q92781 AK293313 BAG56833 AK307157 BC028298 AAH28298 BI765016 BP381700 BU617433 BU731044 DQ426887 HQ447382 ADQ31868 U43559 AAC50725 U89717 AAB93668 NM_001199771 NP_001186700 NM_002905 NP_002896
|
| Function |
Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. {ECO:0000269|PubMed:10588954, ECO:0000269|PubMed:9115228}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:11675386}; Peripheral membrane protein {ECO:0000269|PubMed:11675386}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:11675386}.
|
| Tissue Specificity |
Abundant in the retinal pigment epithelium. Expressed at high levels in mammary tissue, kidney and testis, and at lower levels in liver, heart, adrenal gland, lung, pancreas and skeletal muscle. {ECO:0000269|PubMed:9115228}.
|
| Top Pathways |
Retinol metabolism
|
![Western Blot: RDH5 Overexpression Lysate (Adult Normal) [NBL1-15259] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RDH5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3461_RDH5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15259-img0002.jpg)