Gene Symbol | RDH5 |
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Entrez Gene | 5959 |
Alt Symbol | 9cRDH, HSD17B9, RDH1, SDR9C5 |
Species | Human |
Gene Type | protein-coding |
Description | retinol dehydrogenase 5 (11-cis/9-cis) |
Other Description | 11-cis RDH|11-cis RoDH|11-cis retinol dehydrogenase|9-cis retinol dehydrogenase|9-cis-retinol specific dehydrogenase|retinol dehydrogenase 1|retinol dehydrogenase 5 (11-cis and 9-cis)|short chain dehydrogenase/reductase family 9C member 5|short chain dehydrogenase/reductase family 9C, member 5 |
Swissprots | O00179 Q92781 Q8TAI2 |
Accessions | AAC09250 EAW96825 EAW96826 Q92781 AK293313 BAG56833 AK307157 BC028298 AAH28298 BI765016 BP381700 BU617433 BU731044 DQ426887 HQ447382 ADQ31868 U43559 AAC50725 U89717 AAB93668 NM_001199771 NP_001186700 NM_002905 NP_002896 |
Function | Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. {ECO:0000269|PubMed:10588954, ECO:0000269|PubMed:9115228}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:11675386}; Peripheral membrane protein {ECO:0000269|PubMed:11675386}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:11675386}. |
Tissue Specificity | Abundant in the retinal pigment epithelium. Expressed at high levels in mammary tissue, kidney and testis, and at lower levels in liver, heart, adrenal gland, lung, pancreas and skeletal muscle. {ECO:0000269|PubMed:9115228}. |
Top Pathways | Retinol metabolism |
Human RDH5 protein fragment - ab159323 from Abcam
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RDH1 / RDH5 Antibody Blocking Peptide - LS-E27382 from LifeSpan Bioscience
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RDH1 / RDH5 Antibody Blocking Peptide - LS-E27383 from LifeSpan Bioscience
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Recombinant Human RDH5 Protein - H00005959-Q01 from Novus Biologicals
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RDH5 blocking peptide - GTX88104-PEP from GeneTex
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Goat anti RDH5 antibody Immunizing peptide - orb17560 from Biorbyt
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RDH5 Peptide - AC21-2207-P from Abcore
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RDH5 Peptide - AC21-2208-P from Abcore
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RDH5 / RDH1 - H00005959-Q01-10 from Acris Antibodies
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RDH5 / RDH1 - H00005959-Q01-25 from Acris Antibodies
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RDH5 Peptide - 42-600P from ProSci
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RDH5 Peptide - 42-601P from ProSci
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RDH5 fusion protein - Ag3784 from Proteintech Group
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Recombinant Human RDH5, GST-tagged - RDH5-2240H from Creative Biomart
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Recombinant Human 11-cis retinol dehydrogenase(RDH5) - CSB-YP856423HU CSB-EP856423HU CSB-BP856423HU CSB-MP856423HU from Cusabio
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11-cis retinol dehydrogenase (RDH5), Recombinant Protein - MBS1350349 from MyBioSource
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RDH5 Protein - abx164002 from Abbexa
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RDH5, Peptide - MBS428563 from MyBioSource
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RDH5, Peptide - MBS427318 from MyBioSource
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RDH5 Peptide, Human - M34GP13134H from Creative Peptides
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RDH5 Immunizing peptide - orb16963 from Biorbyt
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RDH5 Recombinant Protein Antigen - NBP2-56636PEP from Novus Biologicals
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