| Gene Symbol | RDH5 |
|---|---|
| Entrez Gene | 5959 |
| Alt Symbol | 9cRDH, HSD17B9, RDH1, SDR9C5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | retinol dehydrogenase 5 (11-cis/9-cis) |
| Other Description | 11-cis RDH|11-cis RoDH|11-cis retinol dehydrogenase|9-cis retinol dehydrogenase|9-cis-retinol specific dehydrogenase|retinol dehydrogenase 1|retinol dehydrogenase 5 (11-cis and 9-cis)|short chain dehydrogenase/reductase family 9C member 5|short chain dehydrogenase/reductase family 9C, member 5 |
| Swissprots | O00179 Q92781 Q8TAI2 |
| Accessions | AAC09250 EAW96825 EAW96826 Q92781 AK293313 BAG56833 AK307157 BC028298 AAH28298 BI765016 BP381700 BU617433 BU731044 DQ426887 HQ447382 ADQ31868 U43559 AAC50725 U89717 AAB93668 NM_001199771 NP_001186700 NM_002905 NP_002896 |
| Function | Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all- trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP. {ECO:0000269|PubMed:10588954, ECO:0000269|PubMed:9115228}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:11675386}; Peripheral membrane protein {ECO:0000269|PubMed:11675386}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:11675386}. |
| Tissue Specificity | Abundant in the retinal pigment epithelium. Expressed at high levels in mammary tissue, kidney and testis, and at lower levels in liver, heart, adrenal gland, lung, pancreas and skeletal muscle. {ECO:0000269|PubMed:9115228}. |
| Top Pathways | Retinol metabolism |