| Gene Symbol |
JCHAIN
|
| Entrez Gene |
3512
|
| Alt Symbol |
IGCJ, IGJ, JCH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
joining chain of multimeric IgA and IgM
|
| Other Description |
IgJ chain|J chain|immunoglobulin J chain|immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
|
| Swissprots |
P01591
|
| Accessions |
AAA58902 CAE93903 CAE93904 CBU30463 EAX05626 P01591 AK312014 BAG34952 BC038982 AAH38982 BP221304 BP261870 BP418109 BX648421 DQ884395 ABI63362 XM_006714211 XP_006714274 XM_006714212 XP_006714275 XM_011531925 XP_011530227 XM_011531926 XP_011530228 NM_144646 NP_653247
|
| Function |
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
|
| Subcellular Location |
Secreted.
|
![Western Blot: IgJ Overexpression Lysate (Adult Normal) [NBL1-11879] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IgJ.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6475_IgJ%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11879-img0002.jpg)