Gene Symbol | JCHAIN |
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Entrez Gene | 3512 |
Alt Symbol | IGCJ, IGJ, JCH |
Species | Human |
Gene Type | protein-coding |
Description | joining chain of multimeric IgA and IgM |
Other Description | IgJ chain|J chain|immunoglobulin J chain|immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
Swissprots | P01591 |
Accessions | AAA58902 CAE93903 CAE93904 CBU30463 EAX05626 P01591 AK312014 BAG34952 BC038982 AAH38982 BP221304 BP261870 BP418109 BX648421 DQ884395 ABI63362 XM_006714211 XP_006714274 XM_006714212 XP_006714275 XM_011531925 XP_011530227 XM_011531926 XP_011530228 NM_144646 NP_653247 |
Function | Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component. |
Subcellular Location | Secreted. |
Ig J Chain CRISPR/Cas9 KO Plasmid (h) - sc-403642 from Santa Cruz Biotechnology
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Ig J Chain HDR Plasmid (h) - sc-403642-HDR from Santa Cruz Biotechnology
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Ig J Chain Double Nickase Plasmid (h) - sc-403642-NIC from Santa Cruz Biotechnology
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Ig J Chain Double Nickase Plasmid (h2) - sc-403642-NIC-2 from Santa Cruz Biotechnology
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Ig J Chain CRISPR Activation Plasmid (h) - sc-403642-ACT from Santa Cruz Biotechnology
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Ig J Chain CRISPR Activation Plasmid (h2) - sc-403642-ACT-2 from Santa Cruz Biotechnology
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Ig J Chain Lentiviral Activation Particles (h) - sc-403642-LAC from Santa Cruz Biotechnology
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Ig J Chain Lentiviral Activation Particles (h2) - sc-403642-LAC-2 from Santa Cruz Biotechnology
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Ig J chain siRNA (h) - sc-45773 from Santa Cruz Biotechnology
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Ig J chain shRNA Plasmid (h) - sc-45773-SH from Santa Cruz Biotechnology
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Ig J chain shRNA (h) Lentiviral Particles - sc-45773-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU043471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10534 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10534 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03421 from Sigma-Aldrich
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IGJ siRNA (Human) - CRH2364 from Cohesion Biosciences
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IGJ - MBS8200376 from MyBioSource
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shRNA set against Human IGJ (NM_144646.3) - SHH317737 from Creative biogene
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IGJ shRNA Plasmid (Human) - CHH2364 from Cohesion Biosciences
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IGJ miRNA 3'UTR clone - MiUTR3H-01244 from Creative biogene
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