EPHB6

Gene Symbol EPHB6
Entrez Gene 2051
Alt Symbol HEP
Species Human
Gene Type protein-coding
Description EPH receptor B6
Other Description ephrin type-B receptor 6|human kinase-defective Eph-family receptor protein|tyrosine-protein kinase-defective receptor EPH-6
Swissprots A4D2I7 O15197 Q2TB24 D3DXD3 A8CDT5 Q2TB23
Accessions AAD03058 AAP20939 EAL23775 EAW51900 EAW51901 EAW51902 EAW51903 O15197 AL832533 BC015495 BC047892 BC051028 BC056159 BC110606 AAI10607 BC110607 AAI10608 BM665491 BX410199 BX414750 CN283348 D83492 BAA21560 EU054308 ABV55388 HY096414 XM_006715881 XP_006715944 XM_011515879 XP_011514181 XM_011515880 XP_011514182 XM_011515881 XP_011514183 XM_011515882 XP_011514184 XM_011546506 XP_011544808 XM_011546507 XP_011544809 XM_011546508 XP_011544810 XM_011546509 XP_011544811 XM_011546510 XP_011544812 XM_011546511 XP_011544813 NM_001280794 NP_001267723 NM_001280795 NP_001267724 NM_004445 NP_004436 NR_104001
Function Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues. {ECO:0000269|PubMed:18754880, ECO:0000269|PubMed:19234485, ECO:0000269|PubMed:9207182}.
Top Pathways Axon guidance

EphB6 Antibody - 12560 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, untransfected (-) or transfected with EphB6 overexpression vector (+), using EphB6 Antibody.

EphB6 (2A6B9) - sc-130053 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EphB6 (2A6B9): sc-130053. Western blot analysis of truncated human recombinant EphB6 protein.

EphB6 (C-20) - sc-7283 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EphB6 (D-7) - sc-398795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EphB6 (D-7): sc-398795. Western blot analysis of EphB6 expression in PC-12 (A) and Jurkat (B) whole cell lysates.

EphB6 (H-90) - sc-25461 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphB6 (H-90): sc-25461. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing membrane and cytoplasmic staining of neuronal cells.

EphB6 (N-19) - sc-7282 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EphB6 (N-19): sc-7282. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing cytoplasmic staining of neuronal cells and glial cells.

EphB6 (11D4) - sc-134332 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
EphB6 (11D4): sc-134332. Western blot analysis of EphB6 expression in PC-12 whole cell lysate.

Anti-Eph receptor B6 antibody - ab70181 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor B6 antibody (ab70181) at 1/500 dilutionLane 1 : Extracts from HeLa cellsLane 2 : Extracts from 293 cellsLane 3 : Extracts from COLO cellsLane 4 : Extracts from COLO cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Eph receptor B6 antibody - ab54656 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Eph receptor B6 antibody (ab54656) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human pancreas.

Anti-Eph receptor B6 antibody - ab174493 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Eph receptor B6 antibody (ab174493) at 1/100 dilution + Jurkat cell line lysate at 35 µg

Anti-Eph receptor B6 antibody [2A6B9] - ab66325 from Abcam

Host Mouse
Clonality Monoclonal
Clone 2A6B9
Anti-Eph receptor B6 antibody [2A6B9] (ab66325) at 1/500 dilution + truncated Eph receptor B6 recombinant protein at 1 µg

Anti-Eph receptor B6 antibody - C-terminal - ab139376 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lanes 1 - 3 : Anti-Eph receptor B6 antibody - C-terminal (ab139376) at 1/500 dilutionLane 4 : Lane 1 : extract from HeLa cellsLane 2 : extract from 296 cellsLane 3 : extract from COLO 205 cellsLane 4 : extract from COLO 205 cells with synthesized peptide

Anti-HEP / EPHB6 Antibody (Extracellular Domain) - LS-C125539 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-HEP / EPHB6 Antibody (Internal) - LS-C155209 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB6 / EPH Receptor B6 Antibody - LS-C109455 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: H1299. A: Hela. 7.5% SDS PAGE. EPHB6 antibody diluted at 1:1000.

Anti-EPHB6 / EPH Receptor B6 Antibody (aa503-530, AP) - LS-C256759 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB6 / EPH Receptor B6 Antibody (aa503-530, APC) - LS-C256758 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB6 / EPH Receptor B6 Antibody (aa990-1021) - LS-C100291 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-EPHB6 / EPH Receptor B6 Antibody (aa503-530, Biotin) - LS-C256760 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB6 / EPH Receptor B6 Antibody (aa503-530, FITC) - LS-C256761 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB6 / EPH Receptor B6 Antibody (aa503-530, Azide-free, HRP) - LS-C256762 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB6 / EPH Receptor B6 Antibody (aa503-530, PE) - LS-C256764 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB6 / EPH Receptor B6 Antibody (N-Terminus, AP) - LS-C277143 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB6 / EPH Receptor B6 Antibody (clone 2A6B9) - LS-C108796 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A6B9
IHC of paraffin-embedded human lymph node (left) and brain (right), showing cytoplasmic localization with DAB staining using EhpB6 mouse monoclonal antibody.

Anti-EPHB6 / EPH Receptor B6 Antibody (aa831-843) IHC-plus™ - LS-B5134 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-EPHB6 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5134 concentration 3.75 ug/ml.
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