EPHB6

Gene Symbol	EPHB6
Entrez Gene	2051
Alt Symbol	HEP
Species	Human
Gene Type	protein-coding
Description	EPH receptor B6
Other Description	ephrin type-B receptor 6|human kinase-defective Eph-family receptor protein|tyrosine-protein kinase-defective receptor EPH-6
Swissprots	A4D2I7 O15197 Q2TB24 D3DXD3 A8CDT5 Q2TB23
Accessions	AAD03058 AAP20939 EAL23775 EAW51900 EAW51901 EAW51902 EAW51903 O15197 AL832533 BC015495 BC047892 BC051028 BC056159 BC110606 AAI10607 BC110607 AAI10608 BM665491 BX410199 BX414750 CN283348 D83492 BAA21560 EU054308 ABV55388 HY096414 XM_006715881 XP_006715944 XM_011515879 XP_011514181 XM_011515880 XP_011514182 XM_011515881 XP_011514183 XM_011515882 XP_011514184 XM_011546506 XP_011544808 XM_011546507 XP_011544809 XM_011546508 XP_011544810 XM_011546509 XP_011544811 XM_011546510 XP_011544812 XM_011546511 XP_011544813 NM_001280794 NP_001267723 NM_001280795 NP_001267724 NM_004445 NP_004436 NR_104001
Function	Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues. {ECO:0000269|PubMed:18754880, ECO:0000269|PubMed:19234485, ECO:0000269|PubMed:9207182}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Eph receptor B6 protein fragment - ab117060 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human EphB6 Protein - H00002051-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EphB6-Antibody-C-term-H990-Blocking-Peptide - BP7627b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EphB6-Antibody-N-term-S45-Blocking-Peptide - BP7627a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human EphB6 Fc Chimera, CF - 3384-B6-200 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human EphB6 Fc tag protein - orb82985 from Biorbyt Category Protein Prices $238.00, $323.00 Sizes 100 μg, 200 μg Source Human Species Human

Human EphB6 His tag protein - orb83659 from Biorbyt Category Protein Prices $357.00, $417.00 Sizes 100 μg, 200 μg Source Human Species Human

Human EphB6 protein - orb82986 from Biorbyt Category Protein Prices $238.00, $323.00 Sizes 100 μg, 200 μg Source Human Species Human

Cynomolgus EphB6 protein - orb138790 from Biorbyt Category Protein Prices $238.00, $323.00 Sizes 100 μg, 200 μg Source Human Cells

EPHB6 Blocking Peptide - abx062587 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

EPHB6 - H00002051-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EPHB6 - H00002051-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EPHB6 fusion protein - ag15992 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

EPHB6 fusion protein - ag17487 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human EPHB6, Fc tagged - EPHB6-40H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human EPHB6, None tagged - EPHB6-698H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human EPHB6, His tagged - EPHB6-3152H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human EPHB6 - EPHB6-28625TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human EPHB6 - EPHB6-615H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human EPHB6, Fc Chimera - EPHB6-935H from Creative Biomart Category Protein Source NSO Cells Species Human

EphB6 - PN201541 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

Human EphB6 / EphB6 Protein (Fc Tag) - 10197-H02H-100 from Sino Biological Category Protein Source Human Cells Species Human

Human EphB6 / EphB6 Protein - 10197-HCCH-100 from Sino Biological Category Protein Source Human Cells Species Human

Human EphB6 / EphB6 Protein (His Tag) - 10197-H08H-100 from Sino Biological Category Protein Source Human Cells Species Human

EPHB6 Blocking Peptide - CBP1393 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

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