| Gene Symbol | EPHB6 |
|---|---|
| Entrez Gene | 2051 |
| Alt Symbol | HEP |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor B6 |
| Other Description | ephrin type-B receptor 6|human kinase-defective Eph-family receptor protein|tyrosine-protein kinase-defective receptor EPH-6 |
| Swissprots | A4D2I7 O15197 Q2TB24 D3DXD3 A8CDT5 Q2TB23 |
| Accessions | AAD03058 AAP20939 EAL23775 EAW51900 EAW51901 EAW51902 EAW51903 O15197 AL832533 BC015495 BC047892 BC051028 BC056159 BC110606 AAI10607 BC110607 AAI10608 BM665491 BX410199 BX414750 CN283348 D83492 BAA21560 EU054308 ABV55388 HY096414 XM_006715881 XP_006715944 XM_011515879 XP_011514181 XM_011515880 XP_011514182 XM_011515881 XP_011514183 XM_011515882 XP_011514184 XM_011546506 XP_011544808 XM_011546507 XP_011544809 XM_011546508 XP_011544810 XM_011546509 XP_011544811 XM_011546510 XP_011544812 XM_011546511 XP_011544813 NM_001280794 NP_001267723 NM_001280795 NP_001267724 NM_004445 NP_004436 NR_104001 |
| Function | Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues. {ECO:0000269|PubMed:18754880, ECO:0000269|PubMed:19234485, ECO:0000269|PubMed:9207182}. |
| Top Pathways | Axon guidance |