| Gene Symbol |
TPBG
|
| Entrez Gene |
7162
|
| Alt Symbol |
5T4, 5T4AG, M6P1, WAIF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
trophoblast glycoprotein
|
| Other Description |
5T4 oncofetal antigen|5T4 oncofetal trophoblast glycoprotein|5T4 oncotrophoblast glycoprotein|wnt-activated inhibitory factor 1
|
| Swissprots |
A8K555 Q13641
|
| Accessions |
CAA09930 CAF06467 CAF85961 EAW48683 Q13641 AI342491 AI857997 AK074786 AK074790 BAG52001 AK291170 BAF83859 BC037161 AAH37161 Z29083 CAA82324 XM_011536097 XP_011534399 NM_001166392 NP_001159864 NM_006670 NP_006661
|
| Function |
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a- dependent LRP6 internalization. {ECO:0000269|PubMed:22100263}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:24582434}; Single-pass type I membrane protein {ECO:0000269|PubMed:24582434}.
|
| Tissue Specificity |
Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
|