| Gene Symbol |
ARHGEF15
|
| Entrez Gene |
22899
|
| Alt Symbol |
ARGEF15, E5, Ephexin5, Vsm-RhoGEF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho guanine nucleotide exchange factor (GEF) 15
|
| Other Description |
ephexin-5|rho guanine nucleotide exchange factor 15
|
| Swissprots |
Q8N449 Q9H8B4 A8K6G1 O94989
|
| Accessions |
EAW90060 EAW90061 O94989 AB020722 BAA74938 AK023853 AK291626 BAF84315 AK300327 BAG62077 AL601528 BC036749 AAH36749 BQ004849 BQ877184 DA632576 DB279954 XM_011523734 XP_011522036 XM_011523735 XP_011522037 XM_011523736 XP_011522038 XM_011523737 XP_011522039 NM_025014 NP_079290 NM_173728 NP_776089
|
| Function |
Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}.
|
| Subcellular Location |
Cell projection, dendrite {ECO:0000250}. Note=Expressed exclusively in dendrites of the developing hippocampus. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the vascular smooth muscle of coronary artery. {ECO:0000269|PubMed:12775584}.
|