Gene Symbol | ARHGEF15 |
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Entrez Gene | 22899 |
Alt Symbol | ARGEF15, E5, Ephexin5, Vsm-RhoGEF |
Species | Human |
Gene Type | protein-coding |
Description | Rho guanine nucleotide exchange factor (GEF) 15 |
Other Description | ephexin-5|rho guanine nucleotide exchange factor 15 |
Swissprots | Q8N449 Q9H8B4 A8K6G1 O94989 |
Accessions | EAW90060 EAW90061 O94989 AB020722 BAA74938 AK023853 AK291626 BAF84315 AK300327 BAG62077 AL601528 BC036749 AAH36749 BQ004849 BQ877184 DA632576 DB279954 XM_011523734 XP_011522036 XM_011523735 XP_011522037 XM_011523736 XP_011522038 XM_011523737 XP_011522039 NM_025014 NP_079290 NM_173728 NP_776089 |
Function | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. {ECO:0000269|PubMed:12775584}. |
Subcellular Location | Cell projection, dendrite {ECO:0000250}. Note=Expressed exclusively in dendrites of the developing hippocampus. {ECO:0000250}. |
Tissue Specificity | Expressed in the vascular smooth muscle of coronary artery. {ECO:0000269|PubMed:12775584}. |
ARHGEF15 CRISPR/Cas9 KO Plasmid (h) - sc-417687 from Santa Cruz Biotechnology
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ARHGEF15 HDR Plasmid (h) - sc-417687-HDR from Santa Cruz Biotechnology
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ARHGEF15 Double Nickase Plasmid (h) - sc-417687-NIC from Santa Cruz Biotechnology
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ARHGEF15 Double Nickase Plasmid (h2) - sc-417687-NIC-2 from Santa Cruz Biotechnology
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ARHGEF15 CRISPR Activation Plasmid (h) - sc-417687-ACT from Santa Cruz Biotechnology
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ARHGEF15 CRISPR Activation Plasmid (h2) - sc-417687-ACT-2 from Santa Cruz Biotechnology
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ARHGEF15 Lentiviral Activation Particles (h) - sc-417687-LAC from Santa Cruz Biotechnology
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ARHGEF15 Lentiviral Activation Particles (h2) - sc-417687-LAC-2 from Santa Cruz Biotechnology
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ARHGEF15 siRNA (h) - sc-93945 from Santa Cruz Biotechnology
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ARHGEF15 shRNA Plasmid (h) - sc-93945-SH from Santa Cruz Biotechnology
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ARHGEF15 shRNA (h) Lentiviral Particles - sc-93945-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU101411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3446 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3446 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09615 from Sigma-Aldrich
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ARHGEF15 siRNA (Human) - CRH7854 from Cohesion Biosciences
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ARHGEF15 - MBS8222305 from MyBioSource
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shRNA set against Human Arhgef15 (NM_173728.3) - SHH239726 from Creative biogene
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ARHGEF15 shRNA Plasmid (Human) - CHH7854 from Cohesion Biosciences
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ARHGEF15 miRNA 3'UTR clone - MiUTR3H-10049 from Creative biogene
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