TESC

Gene Symbol	TESC
Entrez Gene	54997
Alt Symbol	CHP3, TSC
Species	Human
Gene Type	protein-coding
Description	tescalcin
Other Description	calcineurin B homologous protein 3|calcineurin-like EF hand protein 3
Swissprots	F5H1Y5 Q9NWT9 Q96BS2
Accessions	EAW98098 EAW98099 EAW98100 EAW98101 Q96BS2 AF443207 AAL35615 AI372964 AI910454 AK000614 BAA91288 BC015221 AAH15221 BE670015 BM666793 BQ434057 BQ949772 DB452909 DQ894644 ABM85570 XM_011538503 XP_011536805 NM_001168325 NP_001161797 NM_017899 NP_060369 NR_031766
Function	Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269|PubMed:17717601, ECO:0000269|PubMed:18321853, ECO:0000269|PubMed:20060826}.
Subcellular Location	Nucleus. Cytoplasm. Membrane {ECO:0000250}. Cell membrane. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Colocalizes with SLC9A1 at the plasma membrane.
Tissue Specificity	Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta. {ECO:0000269|PubMed:11696366, ECO:0000269|PubMed:20060826}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Tescalcin (E-17) - sc-109444 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Tescalcin (H-74) - sc-366654 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Tescalcin (N-13) - sc-109446 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-TESC antibody - ab103695 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa125-174) - LS-C187209 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa88-116, AP) - LS-C207754 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa88-116, APC) - LS-C207757 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa88-116, Biotin) - LS-C207758 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa88-116, FITC) - LS-C207759 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa88-116, Azide-free, HRP) - LS-C207760 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa88-116, PE) - LS-C207761 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa148-178) - LS-C325664 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa61-110) - LS-C201687 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa53-102) - LS-C206188 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TESC Antibody (aa88-116) - LS-C161804 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

tescalcin Antibody - NBP2-13426 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TESC antibody produced in rabbit - HPA053200 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-TESC (C-TERM) antibody produced in rabbit - SAB1301171 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

TESC Antibody - N-terminal region (ARP57059_P050) - ARP57059_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TESC Antibody - C-terminal region (ARP57060_P050) - ARP57060_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TESC Antibody - N-terminal region (ARP72984_P050) - ARP72984_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TESC Antibody - C-terminal region (OAAB02553) - OAAB02553 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

TESC-Antibody-C-term - AP5136b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

TESC antibody - orb35433 from Biorbyt Prices $187.00, $383.00 Sizes 80 μl (Trial size), 400 μl Host Rabbit Clonality Polyclonal

TESC antibody - 70R-20768 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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