| Gene Symbol |
TESC
|
| Entrez Gene |
54997
|
| Alt Symbol |
CHP3, TSC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tescalcin
|
| Other Description |
calcineurin B homologous protein 3|calcineurin-like EF hand protein 3
|
| Swissprots |
F5H1Y5 Q9NWT9 Q96BS2
|
| Accessions |
EAW98098 EAW98099 EAW98100 EAW98101 Q96BS2 AF443207 AAL35615 AI372964 AI910454 AK000614 BAA91288 BC015221 AAH15221 BE670015 BM666793 BQ434057 BQ949772 DB452909 DQ894644 ABM85570 XM_011538503 XP_011536805 NM_001168325 NP_001161797 NM_017899 NP_060369 NR_031766
|
| Function |
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269|PubMed:17717601, ECO:0000269|PubMed:18321853, ECO:0000269|PubMed:20060826}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Membrane {ECO:0000250}. Cell membrane. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Colocalizes with SLC9A1 at the plasma membrane.
|
| Tissue Specificity |
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta. {ECO:0000269|PubMed:11696366, ECO:0000269|PubMed:20060826}.
|