TESC

Gene Symbol TESC
Entrez Gene 54997
Alt Symbol CHP3, TSC
Species Human
Gene Type protein-coding
Description tescalcin
Other Description calcineurin B homologous protein 3|calcineurin-like EF hand protein 3
Swissprots F5H1Y5 Q9NWT9 Q96BS2
Accessions EAW98098 EAW98099 EAW98100 EAW98101 Q96BS2 AF443207 AAL35615 AI372964 AI910454 AK000614 BAA91288 BC015221 AAH15221 BE670015 BM666793 BQ434057 BQ949772 DB452909 DQ894644 ABM85570 XM_011538503 XP_011536805 NM_001168325 NP_001161797 NM_017899 NP_060369 NR_031766
Function Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269|PubMed:17717601, ECO:0000269|PubMed:18321853, ECO:0000269|PubMed:20060826}.
Subcellular Location Nucleus. Cytoplasm. Membrane {ECO:0000250}. Cell membrane. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Colocalizes with SLC9A1 at the plasma membrane.
Tissue Specificity Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta. {ECO:0000269|PubMed:11696366, ECO:0000269|PubMed:20060826}.

Tescalcin CRISPR/Cas9 KO Plasmid (h) - sc-408244 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tescalcin HDR Plasmid (h) - sc-408244-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tescalcin Double Nickase Plasmid (h) - sc-408244-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tescalcin Double Nickase Plasmid (h2) - sc-408244-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tescalcin CRISPR Activation Plasmid (h) - sc-408244-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tescalcin CRISPR Activation Plasmid (h2) - sc-408244-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tescalcin Lentiviral Activation Particles (h) - sc-408244-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tescalcin Lentiviral Activation Particles (h2) - sc-408244-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tescalcin siRNA (h) - sc-96026 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tescalcin shRNA Plasmid (h) - sc-96026-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tescalcin shRNA (h) Lentiviral Particles - sc-96026-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

tescalcin RNAi - H00054997-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU153581 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21222 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21222 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01247 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01247

TESC siRNA (Human) - CRJ0392 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TESC - MBS8223122 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TESC (NM_017899.3) - SHH425764 from Creative biogene

Category siRNA
Species Reactivities Human

TESC shRNA Plasmid (Human) - CHJ0392 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TESC miRNA 3'UTR clone - MiUTR3H-11999 from Creative biogene

Species Reactivities Human
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