TESC

Gene Symbol	TESC
Entrez Gene	54997
Alt Symbol	CHP3, TSC
Species	Human
Gene Type	protein-coding
Description	tescalcin
Other Description	calcineurin B homologous protein 3|calcineurin-like EF hand protein 3
Swissprots	F5H1Y5 Q9NWT9 Q96BS2
Accessions	EAW98098 EAW98099 EAW98100 EAW98101 Q96BS2 AF443207 AAL35615 AI372964 AI910454 AK000614 BAA91288 BC015221 AAH15221 BE670015 BM666793 BQ434057 BQ949772 DB452909 DQ894644 ABM85570 XM_011538503 XP_011536805 NM_001168325 NP_001161797 NM_017899 NP_060369 NR_031766
Function	Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269|PubMed:17717601, ECO:0000269|PubMed:18321853, ECO:0000269|PubMed:20060826}.
Subcellular Location	Nucleus. Cytoplasm. Membrane {ECO:0000250}. Cell membrane. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Colocalizes with SLC9A1 at the plasma membrane.
Tissue Specificity	Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta. {ECO:0000269|PubMed:11696366, ECO:0000269|PubMed:20060826}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TESC Antibody Blocking Peptide - LS-E7753 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TESC Antibody Blocking Peptide - LS-E20804 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TESC-Antibody-C-term-Blocking-Peptide - BP5136b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human TESC protein - orb244577 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

TESC fusion protein - ag1596 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TESC, GST-tagged - TESC-3182H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Tescalcin(TESC) - CSB-YP023393HU CSB-BP023393HU CSB-MP023393HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Calcineurin B homologous protein 3 - CSB-EP023393HU from Cusabio Category Protein Source E.coli Species Human

Tescalcin / TESC - TP322650 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Calcineurin B homologous protein 3, Recombinant Protein - MBS1306841 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $965.00, $1,180.00, $1,185.00, $1,185.00, $1,445.00, $1,910.00, $1,910.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 1 mg (E-Coli), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

tescalcin Protein - NBP2-13426PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

TESC Peptide, Human - M34GP15800H from Creative Peptides Category Peptide Source Synthetic. Species Human

TESC Recombinant Protein (OPCA01889) - OPCA01889 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Calcineurin B homologous protein 3 - AP70835 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Calcineurin B homologous protein 3, Recombinant Protein - MBS9420731 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

Recombinant Human Tescalcin (TESC) - RPC22100 from Biomatik Category Protein Prices $187.00, $342.00, $1,692.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Human

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