FXN

Gene Symbol FXN
Entrez Gene 505694
Alt Symbol -
Species Bovine
Gene Type protein-coding
Description frataxin
Other Description frataxin, mitochondrial
Swissprots Q05B87
Accessions DAA26896 Q05B87 BC122620 AAI22621 NM_001080727 NP_001074196
Function Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.
Top Pathways Porphyrin and chlorophyll metabolism

Anti-Frataxin antibody - ab113992 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Frataxin antibody (ab113992) at 1 µg/ml + Rat heart lysate at 10 µg

Anti-Frataxin antibody [17A11] - ab113691 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 17A11
Normal human lymphoblast cells were stained with 1 µg/mL ab113691 (blue) or an equal amount of an isotype control antibody (red) and analyzed by flow cytometry.

Anti-Frataxin antibody [17A11] (HRP) - ab197964 from Abcam

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 17A11
All lanes : Anti-Frataxin antibody [17A11] (HRP) (ab197964) at 1/5000 dilutionLane 1 : Human Heart Mitochondrial lysate (ab110337)Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLysates/proteins at 20 µg per lane.developed using the ECL techniquePerformed under reducing conditions.
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