Gene Symbol |
MAFG
|
Entrez Gene |
4097
|
Alt Symbol |
hMAF
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
|
Other Description |
basic leucine zipper transcription factor MafG|transcription factor MafG
|
Swissprots |
O15525
|
Accessions |
EAW89712 EAW89715 O15525 AA775797 AF059195 AAC14427 AK130699 AL520760 BC006143 BC012327 AAH12327 BC103722 BE258646 BE264273 BF976800 BI763651 BM721518 BQ212603 BU195720 DQ591919 DQ890709 ABM81635 DR156847 U84249 AAC51737 Y11514 CAA72284 XM_011523575 XP_011521877 XM_011523576 XP_011521878 XM_011523577 XP_011521879 XM_011523578 XP_011521880 XM_011523579 XP_011521881 NM_002359 NP_002350 NM_032711 NP_116100
|
Function |
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity). {ECO:0000250}.
|
Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:11154691}.
|
Tissue Specificity |
Highly expressed in skeletal muscle. Also expressed in heart and brain.
|