Gene Symbol | MAFG |
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Entrez Gene | 4097 |
Alt Symbol | hMAF |
Species | Human |
Gene Type | protein-coding |
Description | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G |
Other Description | basic leucine zipper transcription factor MafG|transcription factor MafG |
Swissprots | O15525 |
Accessions | EAW89712 EAW89715 O15525 AA775797 AF059195 AAC14427 AK130699 AL520760 BC006143 BC012327 AAH12327 BC103722 BE258646 BE264273 BF976800 BI763651 BM721518 BQ212603 BU195720 DQ591919 DQ890709 ABM81635 DR156847 U84249 AAC51737 Y11514 CAA72284 XM_011523575 XP_011521877 XM_011523576 XP_011521878 XM_011523577 XP_011521879 XM_011523578 XP_011521880 XM_011523579 XP_011521881 NM_002359 NP_002350 NM_032711 NP_116100 |
Function | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:11154691}. |
Tissue Specificity | Highly expressed in skeletal muscle. Also expressed in heart and brain. |
MafG CRISPR/Cas9 KO Plasmid (h) - sc-401959 from Santa Cruz Biotechnology
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MafG HDR Plasmid (h) - sc-401959-HDR from Santa Cruz Biotechnology
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MafG Double Nickase Plasmid (h) - sc-401959-NIC from Santa Cruz Biotechnology
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MafG Double Nickase Plasmid (h2) - sc-401959-NIC-2 from Santa Cruz Biotechnology
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MafG CRISPR Activation Plasmid (h) - sc-401959-ACT from Santa Cruz Biotechnology
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MafG CRISPR Activation Plasmid (h2) - sc-401959-ACT-2 from Santa Cruz Biotechnology
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MafG Lentiviral Activation Particles (h) - sc-401959-LAC from Santa Cruz Biotechnology
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MafG Lentiviral Activation Particles (h2) - sc-401959-LAC-2 from Santa Cruz Biotechnology
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MafG siRNA (h) - sc-38099 from Santa Cruz Biotechnology
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MafG shRNA Plasmid (h) - sc-38099-SH from Santa Cruz Biotechnology
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MafG shRNA (h) Lentiviral Particles - sc-38099-V from Santa Cruz Biotechnology
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MafG RNAi - H00004097-R02 from Novus Biologicals
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MafG RNAi - H00004097-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN12905 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12905 from Sigma-Aldrich
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MAFG siRNA (Human) - CRH2778 from Cohesion Biosciences
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MAFG shRNA Plasmid (Human) - CHH2778 from Cohesion Biosciences
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MAFG miRNA 3'UTR clone - MiUTR4H-TG05270 from Creative biogene
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