SPINK5

Gene Symbol SPINK5
Entrez Gene 11005
Alt Symbol LEKTI, LETKI, NETS, NS, VAKTI
Species Human
Gene Type protein-coding
Description serine peptidase inhibitor, Kazal type 5
Other Description lympho-epithelial Kazal-type-related inhibitor|lymphoepithelial Kazal-type-related inhibitor|serine protease inhibitor Kazal-type 5|serine protease inhibitor, Kazal type 5
Swissprots A8MYE8 Q3LX97 Q9NQ38 D6REN5 Q96PP3 Q96PP2 B7WPB7 Q3LX95 O75770 Q3LX96
Accessions AAK97139 AAK97140 CAB96877 EAW61815 Q9NQ38 AF086524 AF147363 AI341060 AJ228139 CAB40839 AK025197 AK299455 BAG61426 AK301660 BAG63135 AK307588 AK307648 AK309753 BC141545 AAI41546 BI256857 BX648792 DQ149927 ABA06534 DQ149928 ABA06535 DQ149929 ABA06536 DR421881 XM_011537550 XP_011535852 XM_011537551 XP_011535853 NM_001127698 NP_001121170 NM_001127699 NP_001121171 NM_006846 NP_006837
Function Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. {ECO:0000269|PubMed:10419450, ECO:0000269|PubMed:17596512, ECO:0000269|PubMed:20533828}.
Subcellular Location Secreted.
Tissue Specificity Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. {ECO:0000269|PubMed:10419450}.

LEKTI (C-14) - sc-30852 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LEKTI (N-15) - sc-30847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LEKTI (L-16) - sc-30849 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LEKTI (L-16): sc-30849. Western blot analysis of human recombinant LEKTI fusion protein.

LEKTI (1C11G6) - sc-32330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LEKTI (1C11G6): sc-32330. Western blot analysis of LEKTI expression in LEKTI transfected HEK293T whole cell lysate. Kindly provided by Dr. Clayman, Dr. Jayakumar and Dr. Frederick from the University of Texas M.D. Anderson Cancer Center.

LEKTI (S-13) - sc-30850 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LEKTI (H-300) - sc-48756 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LEKTI (H-300): sc-48756. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing cytoplasmic and membrane staining of surface epithelial cells and non-follicle cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

LEKTI (E-9) - sc-137109 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LEKTI (E-9): sc-137109. Western blot analysis of LEKTI expression in HeLa (A), Hs 732.Sk/Mu (B), SCC-4 (C), SCC-25 (D), C32 (E) and BJ (F) whole cell lysates.

LEKTI (F-2) - sc-166604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LEKTI (F-2): sc-166604. Western blot analysis of LEKTI expression in HeLa (A), SK-N-SH (B), CCD-1064Sk (C), Hs 732.Sk/Mu (D), SCC-4 (E), C32 (F), BJ (G) and U-698-M (H) whole cell lysates.

LEKTI (6A108) - sc-71511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-SPINK5 antibody - ab92582 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SPINK5 antibody (ab92582) at 1/100 dilution + A2058 cell line lysate at 35 µg

Anti-SPINK5 antibody - ab138289 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SPINK5 antibody (ab138289) at 1/500 dilution + COLO205 cell lysate at 30 µg

Anti-SPINK5 antibody [EPR8777] - ab138511 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8777
Immunofluorescent analysis of HeLa cells labeling Spink5 with ab138511 at 1:500 dilution.  

Anti-SPINK5 / LEKTI Antibody (His525) - LS-C193160 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (N-Terminus, AP) - LS-C282964 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (N-Terminus, Biotin) - LS-C282966 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (N-Terminus, FITC) - LS-C282967 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (N-Terminus, APC) - LS-C282968 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (N-Terminus, Azide-free, HRP) - LS-C282969 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (N-Terminus, PE) - LS-C282970 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (aa476-525) - LS-C200718 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from COLO205 cells using SPINK5 antibody.

Anti-SPINK5 / LEKTI Antibody - LS-C285819 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (aa494-543) - LS-C291383 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (aa699-976, Biotin) - LS-C298604 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (aa734-995, Biotin) - LS-C297648 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SPINK5 / LEKTI Antibody (aa734-995, Biotin) - LS-C301032 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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