| Gene Symbol |
SPINK5
|
| Entrez Gene |
11005
|
| Alt Symbol |
LEKTI, LETKI, NETS, NS, VAKTI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine peptidase inhibitor, Kazal type 5
|
| Other Description |
lympho-epithelial Kazal-type-related inhibitor|lymphoepithelial Kazal-type-related inhibitor|serine protease inhibitor Kazal-type 5|serine protease inhibitor, Kazal type 5
|
| Swissprots |
A8MYE8 Q3LX97 Q9NQ38 D6REN5 Q96PP3 Q96PP2 B7WPB7 Q3LX95 O75770 Q3LX96
|
| Accessions |
AAK97139 AAK97140 CAB96877 EAW61815 Q9NQ38 AF086524 AF147363 AI341060 AJ228139 CAB40839 AK025197 AK299455 BAG61426 AK301660 BAG63135 AK307588 AK307648 AK309753 BC141545 AAI41546 BI256857 BX648792 DQ149927 ABA06534 DQ149928 ABA06535 DQ149929 ABA06536 DR421881 XM_011537550 XP_011535852 XM_011537551 XP_011535853 NM_001127698 NP_001121170 NM_001127699 NP_001121171 NM_006846 NP_006837
|
| Function |
Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. {ECO:0000269|PubMed:10419450, ECO:0000269|PubMed:17596512, ECO:0000269|PubMed:20533828}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. {ECO:0000269|PubMed:10419450}.
|