SPINK5

Gene Symbol SPINK5
Entrez Gene 11005
Alt Symbol LEKTI, LETKI, NETS, NS, VAKTI
Species Human
Gene Type protein-coding
Description serine peptidase inhibitor, Kazal type 5
Other Description lympho-epithelial Kazal-type-related inhibitor|lymphoepithelial Kazal-type-related inhibitor|serine protease inhibitor Kazal-type 5|serine protease inhibitor, Kazal type 5
Swissprots A8MYE8 Q3LX97 Q9NQ38 D6REN5 Q96PP3 Q96PP2 B7WPB7 Q3LX95 O75770 Q3LX96
Accessions AAK97139 AAK97140 CAB96877 EAW61815 Q9NQ38 AF086524 AF147363 AI341060 AJ228139 CAB40839 AK025197 AK299455 BAG61426 AK301660 BAG63135 AK307588 AK307648 AK309753 BC141545 AAI41546 BI256857 BX648792 DQ149927 ABA06534 DQ149928 ABA06535 DQ149929 ABA06536 DR421881 XM_011537550 XP_011535852 XM_011537551 XP_011535853 NM_001127698 NP_001121170 NM_001127699 NP_001121171 NM_006846 NP_006837
Function Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. {ECO:0000269|PubMed:10419450, ECO:0000269|PubMed:17596512, ECO:0000269|PubMed:20533828}.
Subcellular Location Secreted.
Tissue Specificity Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. {ECO:0000269|PubMed:10419450}.

LEKTI CRISPR/Cas9 KO Plasmid (h) - sc-402594 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEKTI HDR Plasmid (h) - sc-402594-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEKTI Double Nickase Plasmid (h) - sc-402594-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEKTI Double Nickase Plasmid (h2) - sc-402594-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEKTI CRISPR Activation Plasmid (h) - sc-402594-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEKTI CRISPR Activation Plasmid (h2) - sc-402594-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEKTI Lentiviral Activation Particles (h) - sc-402594-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEKTI Lentiviral Activation Particles (h2) - sc-402594-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LEKTI siRNA (h) - sc-45358 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LEKTI shRNA Plasmid (h) - sc-45358-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LEKTI shRNA (h) Lentiviral Particles - sc-45358-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU077751 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20483 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20483 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03300 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03300

SPINK5 siRNA (Human) - CRH7515 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPINK5 - MBS8228741 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human SPINK5 siRNA - orb268017 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPINK5 shRNA Plasmid (Human) - CHH7515 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPINK5 miRNA 3'UTR clone - MiUTR3H-07294 from Creative biogene

Species Reactivities Human

SPINK5 miRNA 3'UTR clone - MiUTR3H-07295 from Creative biogene

Species Reactivities Human

SPINK5 miRNA 3'UTR clone - MiUTR3H-07296 from Creative biogene

Species Reactivities Human
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