Gene Symbol | NEK11 |
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Entrez Gene | 79858 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | NIMA-related kinase 11 |
Other Description | NIMA (never in mitosis gene a)- related kinase 11|serine/threonine-protein kinase Nek11 |
Swissprots | Q9H5F4 A6NHD7 Q8TBY1 Q8NG66 Q8NG65 Q5JPC0 |
Accessions | EAW79212 EAW79213 Q8NG66 AB071996 BAC06350 AB071997 BAC06351 AK027148 BAB15672 AK123021 AK293261 BAG56793 AK297300 BAG59768 AK316352 BAH14723 AL833472 CAI46114 BC009414 BC026195 BC028587 AAH28587 BU674219 BX328072 XM_005247783 XP_005247840 XM_005247785 XP_005247842 XM_006713749 XP_006713812 XM_011513165 XP_011511467 XM_011513166 XP_011511468 XM_011513167 XP_011511469 XM_011513168 XP_011511470 XM_011513169 XP_011511471 XM_011513170 XP_011511472 XM_011513171 XP_011511473 XM_011513172 XP_011511474 XM_011513173 XP_011511475 XM_011513174 XP_011511476 XM_011513175 XP_011511477 XM_011513176 XP_011511478 XM_011513177 XP_011511479 XM_011513178 XP_011511480 XM_011513179 XP_011511481 XM_011513180 XP_011511482 XM_011513181 XP_011511483 XM_011513182 XP_011511484 XR_924179 NM_001146003 NP_001139475 NM_024800 NP_079076 NM_145910 NP_665917 |
Function | Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}. |
Subcellular Location | Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S- arrested cells. |
Tissue Specificity | Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. {ECO:0000269|PubMed:12154088}. |
Nek11 (N-13) - sc-99566 from Santa Cruz Biotechnology
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Nek11 (G-15) - sc-99565 from Santa Cruz Biotechnology
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Nek11 (36JK) - sc-100429 from Santa Cruz Biotechnology
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Anti-NEK11 antibody - ab57747 from Abcam
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Anti-NEK11 antibody - ab37638 from Abcam
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Anti-NEK11 antibody - ab71813 from Abcam
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Anti-NEK11 antibody - ab155220 from Abcam
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Anti-NEK11 antibody - ab17015 from Abcam
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Anti-NEK11 antibody [5E9] - ab119086 from Abcam
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Anti-NEK11 antibody - C-terminal - ab199144 from Abcam
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Anti-NEK11 Antibody (C-Terminus, AP) - LS-C225987 from LifeSpan Bioscience
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Anti-NEK11 Antibody (aa504-553) - LS-C111205 from LifeSpan Bioscience
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Anti-NEK11 Antibody (C-Terminus, APC) - LS-C225988 from LifeSpan Bioscience
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Anti-NEK11 Antibody (C-Terminus, Biotin) - LS-C225989 from LifeSpan Bioscience
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Anti-NEK11 Antibody (C-Terminus, FITC) - LS-C225990 from LifeSpan Bioscience
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Anti-NEK11 Antibody (C-Terminus, Azide-free, HRP) - LS-C225992 from LifeSpan Bioscience
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Anti-NEK11 Antibody (C-Terminus, PE) - LS-C225991 from LifeSpan Bioscience
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Anti-NEK11 Antibody (Internal) - LS-C345464 from LifeSpan Bioscience
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Anti-NEK11 Antibody (aa480-510) - LS-C101162 from LifeSpan Bioscience
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Anti-NEK11 Antibody (clone 4H5) - LS-C115535 from LifeSpan Bioscience
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Anti-NEK11 Antibody (clone 4E1-1F4) - LS-C133817 from LifeSpan Bioscience
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Anti-NEK11 Antibody (clone 5D9) - LS-C172396 from LifeSpan Bioscience
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NEK11 Antibody (4E1-1F4) - H00079858-M01 from Novus Biologicals
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NEK11 Antibody - NBP1-83584 from Novus Biologicals
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NEK11 Antibody - NBP2-19509 from Novus Biologicals
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