| Gene Symbol |
NEK11
|
| Entrez Gene |
79858
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NIMA-related kinase 11
|
| Other Description |
NIMA (never in mitosis gene a)- related kinase 11|serine/threonine-protein kinase Nek11
|
| Swissprots |
Q9H5F4 A6NHD7 Q8TBY1 Q8NG66 Q8NG65 Q5JPC0
|
| Accessions |
EAW79212 EAW79213 Q8NG66 AB071996 BAC06350 AB071997 BAC06351 AK027148 BAB15672 AK123021 AK293261 BAG56793 AK297300 BAG59768 AK316352 BAH14723 AL833472 CAI46114 BC009414 BC026195 BC028587 AAH28587 BU674219 BX328072 XM_005247783 XP_005247840 XM_005247785 XP_005247842 XM_006713749 XP_006713812 XM_011513165 XP_011511467 XM_011513166 XP_011511468 XM_011513167 XP_011511469 XM_011513168 XP_011511470 XM_011513169 XP_011511471 XM_011513170 XP_011511472 XM_011513171 XP_011511473 XM_011513172 XP_011511474 XM_011513173 XP_011511475 XM_011513174 XP_011511476 XM_011513175 XP_011511477 XM_011513176 XP_011511478 XM_011513177 XP_011511479 XM_011513178 XP_011511480 XM_011513179 XP_011511481 XM_011513180 XP_011511482 XM_011513181 XP_011511483 XM_011513182 XP_011511484 XR_924179 NM_001146003 NP_001139475 NM_024800 NP_079076 NM_145910 NP_665917
|
| Function |
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S- arrested cells.
|
| Tissue Specificity |
Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. {ECO:0000269|PubMed:12154088}.
|