Dio3
| Gene Symbol | Dio3 |
|---|---|
| Entrez Gene | 29475 |
| Alt Symbol | 5DIII, DIOIII |
| Species | Rat |
| Gene Type | protein-coding |
| Description | deiodinase, iodothyronine, type III |
| Other Description | deiodinase, iodothyronine, type 3|type 3 DI|type III iodothyronine deiodinase|type-III 5'-deiodinase |
| Swissprots | P49897 |
| Accessions | EDL97515 P49897 BM414881 U24282 AAC52241 NM_017210 NP_058906 |
| Function | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Neonatal skin, placenta, skeletal muscle and cerebral cortex. {ECO:0000269|PubMed:7622463}. |
Anti-DIO3 Antibody (Internal, DY650) - LS-C141515 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal, Biotin) - LS-C141514 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal, DY488) - LS-C141516 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal, HRP) - LS-C141517 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal, DY550) - LS-C141518 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal, Biotin) - LS-C142485 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal, DY650) - LS-C142486 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal, DY488) - LS-C142487 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal, HRP) - LS-C142488 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal) - LS-C142484 from LifeSpan Bioscience
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Anti-DIO3 Antibody (Internal, DY550) - LS-C142489 from LifeSpan Bioscience
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Anti-DIO3 Antibody (aa11-277, Biotin) - LS-C298497 from LifeSpan Bioscience
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Anti-DIO3 Antibody (aa11-277, FITC) - LS-C305153 from LifeSpan Bioscience
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Anti-DIO3 Antibody (aa11-277) - LS-C293665 from LifeSpan Bioscience
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Anti -DIO3 (ITDI3, TXDI3, Type III Iodothyronine Deiodinase, 5DIII, DIOIII, Type 3 DI,Type-III 5'-deiodinase) - 140043 from USBiological Life Science
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Anti -DIO3 (ITDI3, TXDI3, Type III Iodothyronine Deiodinase, 5DIII, DIOIII, Type 3 DI,Type-III 5'-deiodinase) (AP) - 140043-AP from USBiological Life Science
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Anti -DIO3 (ITDI3, TXDI3, Type III Iodothyronine Deiodinase, 5DIII, DIOIII, Type 3 DI,Type-III 5'-deiodinase) (APC) - 140043-APC from USBiological Life Science
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Anti -DIO3 (ITDI3, TXDI3, Type III Iodothyronine Deiodinase, 5DIII, DIOIII, Type 3 DI,Type-III 5'-deiodinase) (Biotin) - 140043-Biotin from USBiological Life Science
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Anti -DIO3 (ITDI3, TXDI3, Type III Iodothyronine Deiodinase, 5DIII, DIOIII, Type 3 DI,Type-III 5'-deiodinase) (FITC) - 140043-FITC from USBiological Life Science
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Anti -DIO3 (ITDI3, TXDI3, Type III Iodothyronine Deiodinase, 5DIII, DIOIII, Type 3 DI,Type-III 5'-deiodinase) (HRP) - 140043-HRP from USBiological Life Science
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Anti -DIO3 (ITDI3, TXDI3, Type III Iodothyronine Deiodinase, 5DIII, DIOIII, Type 3 DI,Type-III 5'-deiodinase) (PE) - 140043-PE from USBiological Life Science
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DIO3 Antibody - abx103701 from Abbexa
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Type III iodothyronine deiodinase Antibody - abx110669 from Abbexa
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Type III iodothyronine deiodinase Antibody (Biotin) - abx106403 from Abbexa
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Type III iodothyronine deiodinase Antibody (FITC) - abx107815 from Abbexa
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