| Gene Symbol |
Dio3
|
| Entrez Gene |
29475
|
| Alt Symbol |
5DIII, DIOIII
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
deiodinase, iodothyronine, type III
|
| Other Description |
deiodinase, iodothyronine, type 3|type 3 DI|type III iodothyronine deiodinase|type-III 5'-deiodinase
|
| Swissprots |
P49897
|
| Accessions |
EDL97515 P49897 BM414881 U24282 AAC52241 NM_017210 NP_058906
|
| Function |
Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Neonatal skin, placenta, skeletal muscle and cerebral cortex. {ECO:0000269|PubMed:7622463}.
|