Nkx3-1

Gene Symbol Nkx3-1
Entrez Gene 18095
Alt Symbol Bax, NKX3.1, NKX3A, Nkx-3.1, bagpipe
Species Mouse
Gene Type protein-coding
Description NK-3 transcription factor, locus 1 (Drosophila)
Other Description Drosophila NK-3 transcription factor, locus 1|homeobox protein NK-3 homolog A|homeobox protein Nkx-3.1
Swissprots P97436 O09087
Accessions EDL35951 P97436 AK137281 BAE23291 BC050109 BC132401 AAI32402 BC132427 AAI32428 U73460 AAC52956 U88542 AAB58025 NM_010921 NP_035051
Function Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for appropriate differentiation and secretory function of the bulbourethral gland. {ECO:0000250, ECO:0000269|PubMed:12036903}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
Tissue Specificity Expressed mostly in the male urogenital tract, with highest expression in the epithelial cells lining the ducts of anterior, dorsolateral and ventral prostate and in the bulbourethral gland, and much lower in the seminal vesicle and the testis. Expression in the prostate increases during sexual maturation and is drastically reduced following castration. Expressed also in brain (hippocampus and external granular layer of the cerebral cortex), kidney (intralobular arteries), thymus and adrenal and salivary glands.
Top Pathways Prostate cancer

Nkx-3.1 (M-96) - sc-25406 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Nkx-3.1 (M-96): sc-25406. Western blot analysis of Nkx-3.1 expression in AT-3 whole cell lysate.

Anti-Nkx3.1 antibody - ab175308 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Nkx3.1 antibody (ab175308) at 1/1000 dilution + mouse stomach tissue lysate at 35 µg

Bax Antibody - NB100-56096 from Novus Biologicals

Prices $129.00, $199.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Bax Antibody [NB100-56096] - analysis of Bax in mouse using this antibody. 1. In vitro translated mouse Bax. 2. Normal cortex. 3. Ischemic hippocampus. 4. Ischemic hippocampus. Ishemic samples were prepared 6 hr post middle cerebral artery occlusion. The results show the Bax expression increased following ischemia.

Bax Antibody - NB100-56097 from Novus Biologicals

Prices $129.00, $199.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Bax Antibody [NB100-56097] - analysis of full-length recombinant mouse Bax using this antibody.

NKX3.1 Antibody (738907) - MAB6475 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 738907
NKX3.1 was detected in immersion fixed NIH‑3T3 mouse embryonic fibroblast cell line using Rat Anti-Mouse NKX3.1 Monoclonal Antibody (Catalog # MAB6475) at 25 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red, upper panel; Catalog # NL013) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

NKX3.1 Antibody - AF6475 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of Balb/3T3 mouse embryonic fibroblast cell line and NIH‑3T3 mouse embryonic fibroblast cell line. PVDF Membrane was probed with 1 µg/mL of Mouse NKX3.1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6475) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for NKX3.1 at approximately 38 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Nkx3-1 Antibody - middle region (ARP37115_P050) - ARP37115_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Mouse-Nkx3-1-Antibody-Center - AP19312c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Nkx3-1 Antibody (Center)(Cat. #AP19312c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Nkx3-1 antibody detected the Nkx3-1 protein (arrow).

Bax antibody [5B7] - GTX23191 from GeneTex

Prices $319.00
Sizes 500 μl
Host Mouse
Clonality Monoclonal
Clone 5B7

Nkx3.1 antibody - GTX77649 from GeneTex

Prices $289.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

Anti -BAX (Apoptosis Regulator BAX, Bcl-2-like Protein 4, Bcl2-L-4, BCL2L4) - 139397 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -BAX (Apoptosis Regulator BAX, Bcl-2-like Protein 4, Bcl2-L-4, BCL2L4) (AP) - 139397-AP from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -BAX (Apoptosis Regulator BAX, Bcl-2-like Protein 4, Bcl2-L-4, BCL2L4) (APC) - 139397-APC from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -BAX (Apoptosis Regulator BAX, Bcl-2-like Protein 4, Bcl2-L-4, BCL2L4) (FITC) - 139397-FITC from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -BAX (Apoptosis Regulator BAX, Bcl-2-like Protein 4, Bcl2-L-4, BCL2L4) (HRP) - 139397-HRP from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -BAX (Apoptosis Regulator BAX, Bcl-2-like Protein 4, Bcl2-L-4, BCL2L4) (PE) - 139397-PE from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Bax (Apoptosis Regulator BAX, Bcl-2-like Protein 4, Bcl2-L-4, BCL2L4) - B0175-04G from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Bax (Apoptosis Regulator BAX, Bcl-2-like Protein 4, Bcl2-L-4, BCL2L4) - B0175-04H from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Bax (Apoptosis Regulator BAX, Bcl-2-like Protein 4, Bcl2-L-4, BCL2L4) - B0175-06B from USBiological Life Science

Host Mouse
Clonality Monoclonal

Nkx3-1 Antibody - middle region (OAAB14890) - OAAB14890 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

BAX Polyclonal Antibody (OABB00112) - OABB00112 from Aviva Systems Biology

Prices $255.00
Sizes 100 µg
Clonality Polyclonal

Bax antibody - 10R-6624 from Fitzgerald

Prices $265.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D1
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