Nkx3-1

Gene Symbol Nkx3-1
Entrez Gene 18095
Alt Symbol Bax, NKX3.1, NKX3A, Nkx-3.1, bagpipe
Species Mouse
Gene Type protein-coding
Description NK-3 transcription factor, locus 1 (Drosophila)
Other Description Drosophila NK-3 transcription factor, locus 1|homeobox protein NK-3 homolog A|homeobox protein Nkx-3.1
Swissprots P97436 O09087
Accessions EDL35951 P97436 AK137281 BAE23291 BC050109 BC132401 AAI32402 BC132427 AAI32428 U73460 AAC52956 U88542 AAB58025 NM_010921 NP_035051
Function Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for appropriate differentiation and secretory function of the bulbourethral gland. {ECO:0000250, ECO:0000269|PubMed:12036903}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
Tissue Specificity Expressed mostly in the male urogenital tract, with highest expression in the epithelial cells lining the ducts of anterior, dorsolateral and ventral prostate and in the bulbourethral gland, and much lower in the seminal vesicle and the testis. Expression in the prostate increases during sexual maturation and is drastically reduced following castration. Expressed also in brain (hippocampus and external granular layer of the cerebral cortex), kidney (intralobular arteries), thymus and adrenal and salivary glands.
Top Pathways Prostate cancer

Mouse-Nkx3-1-Antibody-Center-Blocking-Peptide - BP19312c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg
Species Mouse

Mouse BAX protein - orb197743 from Biorbyt

Category Protein
Prices $374.00
Sizes 200 μl
Species Mouse

Mouse Bax (HEK293 Lysate) - orb197725 from Biorbyt

Category Protein
Prices $255.00
Sizes 100 μg
Species Mouse

Mouse BAX protein (GST Tag) - orb80950 from Biorbyt

Category Protein
Prices $170.00, $289.00
Sizes 2 μg, 10 μg
Species Mouse

Bax Mouse - NKX-953 from Reagent Proteins

Category Protein
Prices $348.00, $5,097.00
Sizes 10.00 µg, 1 mg
Source E.coli
Species Mouse

Bax Mouse, GST - NKX-291 from Reagent Proteins

Category Protein
Prices $348.00, $5,097.00
Sizes 10.00 µg, 1 mg
Source E.coli
Species Mouse

BAX - PR27055-2 from Neuromics

Category Protein
Prices $108.00, $205.00
Sizes 2 µg, 10 µg
Species Mouse
Image: BAX Structure and Sequence.

Bax - PPT-20022 from Nordic BioSite

Category Protein
Species Mouse

Bax - PPT-20023 from Nordic BioSite

Category Protein
Species Mouse

Recombinant Mouse Homeobox protein Nkx-3.1(Nkx3-1) - CSB-YP015848MO CSB-EP015848MO CSB-BP015848MO CSB-MP015848MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Bax (1-171) - sc-4239 WB from Santa Cruz Biotechnology

Category Protein
Prices $88.00
Sizes 10 µg/0.1 ml
Species Mouse

Bax Mouse Recombinant ( Bax Mouse ) - PT_39984 from Novatein Biosciences

Prices $175.00, $289.00, $4,704.00
Sizes 2 µg, 10 µg, 1 mg
Species Mouse

Recombinant Mouse NKX3-1 Protein - NKX3-1-10703M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

Bax Mouse Recombinant - Pr20169 from ProMab

Category Protein
Prices $50.00, $130.00, $4,800.00
Sizes 2 μg, 10 μg, 1 mg
Source Escherichia Coli.
Species Mouse

Bax Mouse Recombinant, GST - Pr20170 from ProMab

Category Protein
Prices $50.00, $130.00, $4,800.00
Sizes 2 μg, 10 μg, 1 mg
Source Escherichia Coli.
Species Mouse

Homeobox protein Nkx-3.1 (Nkx3-1), Recombinant Protein - MBS948151 from MyBioSource

Category Protein
Prices $990.00, $990.00, $1,215.00, $1,215.00, $1,500.00, $1,500.00, $1,965.00, $1,965.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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