| Gene Symbol | Nkx3-1 |
|---|---|
| Entrez Gene | 18095 |
| Alt Symbol | Bax, NKX3.1, NKX3A, Nkx-3.1, bagpipe |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | NK-3 transcription factor, locus 1 (Drosophila) |
| Other Description | Drosophila NK-3 transcription factor, locus 1|homeobox protein NK-3 homolog A|homeobox protein Nkx-3.1 |
| Swissprots | P97436 O09087 |
| Accessions | EDL35951 P97436 AK137281 BAE23291 BC050109 BC132401 AAI32402 BC132427 AAI32428 U73460 AAC52956 U88542 AAB58025 NM_010921 NP_035051 |
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for appropriate differentiation and secretory function of the bulbourethral gland. {ECO:0000250, ECO:0000269|PubMed:12036903}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
| Tissue Specificity | Expressed mostly in the male urogenital tract, with highest expression in the epithelial cells lining the ducts of anterior, dorsolateral and ventral prostate and in the bulbourethral gland, and much lower in the seminal vesicle and the testis. Expression in the prostate increases during sexual maturation and is drastically reduced following castration. Expressed also in brain (hippocampus and external granular layer of the cerebral cortex), kidney (intralobular arteries), thymus and adrenal and salivary glands. |
| Top Pathways | Prostate cancer |
Apoptosis regulator BAX, Bax, Mouse, ELISA Kit - E1343m from ARP American Research Products
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Bcl2 Associated X Protein (Bax), Mouse, ELISA Kit - SEB343Mu from ARP American Research Products
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Mouse BAX ELISA Kit - MB0039 from NeoScientific
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Mouse Bax(Bcl-2 Associated X Protein) ELISA Kit - E-EL-M0178 from Elabscience
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Mouse Bax (Bcl-2 Associated X Protein) CLIA Kit - E-CL-M0131 from Elabscience
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Bax, ELISA Kit - MBS2509733 from MyBioSource
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NK3 homeobox 1, ELISA Kit - MBS9337498 from MyBioSource
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Mouse BCL2 Associated X Protein ELISA - E03B0032 from BlueGene Biotech
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Mouse Bax(Bcl-2 Associated X Protein) ELISA Kit - E-EL-M0178 from Iwai North America Inc.
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Mouse Bax (Bcl-2 Associated X Protein) CLIA Kit - E-CL-M0131 from Iwai North America Inc.
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Mouse Bax ELISA Kit - abx153702 from Abbexa
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Bcl2 Associated X Protein (Bax), Mouse, ELISA Kit - DL-Bax-Mu from ARP American Research Products
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Mouse Bax ELISA Kit - orb370089 from Biorbyt
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Mouse Bax ELISA Kit - abx576075 from Abbexa
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Bax - EKM1168 from Nordic BioSite
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Mouse Bax ELISA Kit - E044653 from Biobool
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Mouse Nkx3-1 ELISA Kit - E055998 from Biobool
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Mouse BAX ELISA Kit - EMB0039 from ABclonal
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Mouse Bax (Bcl-2 Associated X Protein) ELISA Kit - EKE61538 from Biomatik
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BAX (Mouse) ELISA Kit - E4512 from Biovision
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