| Gene Symbol | Nkx3-1 |
|---|---|
| Entrez Gene | 18095 |
| Alt Symbol | Bax, NKX3.1, NKX3A, Nkx-3.1, bagpipe |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | NK-3 transcription factor, locus 1 (Drosophila) |
| Other Description | Drosophila NK-3 transcription factor, locus 1|homeobox protein NK-3 homolog A|homeobox protein Nkx-3.1 |
| Swissprots | P97436 O09087 |
| Accessions | EDL35951 P97436 AK137281 BAE23291 BC050109 BC132401 AAI32402 BC132427 AAI32428 U73460 AAC52956 U88542 AAB58025 NM_010921 NP_035051 |
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for appropriate differentiation and secretory function of the bulbourethral gland. {ECO:0000250, ECO:0000269|PubMed:12036903}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
| Tissue Specificity | Expressed mostly in the male urogenital tract, with highest expression in the epithelial cells lining the ducts of anterior, dorsolateral and ventral prostate and in the bulbourethral gland, and much lower in the seminal vesicle and the testis. Expression in the prostate increases during sexual maturation and is drastically reduced following castration. Expressed also in brain (hippocampus and external granular layer of the cerebral cortex), kidney (intralobular arteries), thymus and adrenal and salivary glands. |
| Top Pathways | Prostate cancer |
Nkx-3.1 CRISPR/Cas9 KO Plasmid (m) - sc-421906 from Santa Cruz Biotechnology
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Nkx-3.1 HDR Plasmid (m) - sc-421906-HDR from Santa Cruz Biotechnology
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Nkx-3.1 Double Nickase Plasmid (m) - sc-421906-NIC from Santa Cruz Biotechnology
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Nkx-3.1 Double Nickase Plasmid (m2) - sc-421906-NIC-2 from Santa Cruz Biotechnology
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Nkx-3.1 CRISPR Activation Plasmid (m) - sc-421906-ACT from Santa Cruz Biotechnology
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Nkx-3.1 CRISPR Activation Plasmid (m2) - sc-421906-ACT-2 from Santa Cruz Biotechnology
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Nkx-3.1 Lentiviral Activation Particles (m) - sc-421906-LAC from Santa Cruz Biotechnology
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Nkx-3.1 Lentiviral Activation Particles (m2) - sc-421906-LAC-2 from Santa Cruz Biotechnology
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Nkx-3.1 siRNA (m) - sc-36078 from Santa Cruz Biotechnology
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Nkx-3.1 shRNA Plasmid (m) - sc-36078-SH from Santa Cruz Biotechnology
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Nkx-3.1 shRNA (m) Lentiviral Particles - sc-36078-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU001851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN36490 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36490 from Sigma-Aldrich
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NKX3-1 siRNA (Mouse) - CRM2784 from Cohesion Biosciences
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shRNA set against Mouse Nkx3-1(NM_010921.3) - SHG091693 from Creative biogene
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Mouse NKX3-1 siRNA - orb282260 from Biorbyt
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NKX3-1 shRNA Plasmid (Mouse) - CHM2784 from Cohesion Biosciences
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NKX3-1 miRNA 3'UTR clone - MiUTR1M-07679 from Creative biogene
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