| Gene Symbol |
GUCY2C
|
| Entrez Gene |
2984
|
| Alt Symbol |
DIAR6, GUC2C, MECIL, MUCIL, STAR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
guanylate cyclase 2C
|
| Other Description |
GC-C|STA receptor|guanylyl cyclase C|hSTAR|heat stable enterotoxin receptor|heat-stable enterotoxin receptor|intestinal guanylate cyclase
|
| Swissprots |
P25092 B2RMY6
|
| Accessions |
AAC50381 CCO13742 CDM22032 EAW96324 P25092 AK310034 AW848739 BC136544 AAI36545 BC136545 AAI36546 M73489 AAA36655 S57551 AAB19934 XM_011520631 XP_011518933 NM_004963 NP_004954
|
| Function |
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Note=The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
|
| Top Pathways |
Purine metabolism
|
![Western Blot: GUCY2C Overexpression Lysate (Adult Normal) [NBL1-11409] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GUCY2C.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/731_GUCY2C%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11409-img0002.jpg)