GUCY2C

Gene Symbol	GUCY2C
Entrez Gene	2984
Alt Symbol	DIAR6, GUC2C, MECIL, MUCIL, STAR
Species	Human
Gene Type	protein-coding
Description	guanylate cyclase 2C
Other Description	GC-C|STA receptor|guanylyl cyclase C|hSTAR|heat stable enterotoxin receptor|heat-stable enterotoxin receptor|intestinal guanylate cyclase
Swissprots	P25092 B2RMY6
Accessions	AAC50381 CCO13742 CDM22032 EAW96324 P25092 AK310034 AW848739 BC136544 AAI36545 BC136545 AAI36546 M73489 AAA36655 S57551 AAB19934 XM_011520631 XP_011518933 NM_004963 NP_004954
Function	Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Note=The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GC-C CRISPR/Cas9 KO Plasmid (h) - sc-403413 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GC-C HDR Plasmid (h) - sc-403413-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GC-C Double Nickase Plasmid (h) - sc-403413-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GC-C Double Nickase Plasmid (h2) - sc-403413-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GC-C CRISPR Activation Plasmid (h) - sc-403413-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GC-C CRISPR Activation Plasmid (h2) - sc-403413-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GC-C Lentiviral Activation Particles (h) - sc-403413-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GC-C Lentiviral Activation Particles (h2) - sc-403413-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GC-C siRNA (h) - sc-45492 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GC-C shRNA Plasmid (h) - sc-45492-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GC-C shRNA (h) Lentiviral Particles - sc-45492-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GUCY2C RNAi - H00002984-R04 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® siRNA - SIHK0875 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0877 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0876 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN9802 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9802 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13000 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr13000

GUCY2C siRNA (Human) - CRH2023 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GUCY2C - MBS8207745 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human GUCY2C (NM_004963.3) - SHH309370 from Creative biogene Category siRNA Species Reactivities Human

Human GUCY2C siRNA - orb262525 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GUCY2C shRNA Plasmid (Human) - CHH2023 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

GUCY2C miRNA 3'UTR clone - MiUTR3H-04068 from Creative biogene Species Reactivities Human

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