GUCY2C

Gene Symbol	GUCY2C
Entrez Gene	2984
Alt Symbol	DIAR6, GUC2C, MECIL, MUCIL, STAR
Species	Human
Gene Type	protein-coding
Description	guanylate cyclase 2C
Other Description	GC-C|STA receptor|guanylyl cyclase C|hSTAR|heat stable enterotoxin receptor|heat-stable enterotoxin receptor|intestinal guanylate cyclase
Swissprots	P25092 B2RMY6
Accessions	AAC50381 CCO13742 CDM22032 EAW96324 P25092 AK310034 AW848739 BC136544 AAI36545 BC136545 AAI36546 M73489 AAA36655 S57551 AAB19934 XM_011520631 XP_011518933 NM_004963 NP_004954
Function	Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23269669}; Single-pass type I membrane protein {ECO:0000269|PubMed:23269669}. Note=The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
Top Pathways	Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GUCY2C protein fragment - ab158612 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human GUCY2C Protein - H00002984-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GUCY2C / STA receptor - H00002984-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GUCY2C / STA receptor - H00002984-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GUCY2C fusion protein - Ag19256 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

GUCY2C fusion protein - ag19207 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human GUCY2C, His-tagged - GUCY2C-13620H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Heat-stable enterotoxin receptor(GUCY2C) - CSB-YP010053HU CSB-EP010053HU CSB-BP010053HU CSB-MP010053HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GUCY2C Recombinant Protein Antigen - NBP1-81788PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

GUCY2C-Antibody-C-term-Blocking-Peptide - BP7136b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GUCY2C-Antibody-Center-Blocking-Peptide - BP7136a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GUCY2C Peptide, Human - M34GP06776H from Creative Peptides Category Peptide Source Synthetic. Species Human

Heat-stable enterotoxin receptor (GUCY2C), Recombinant Protein - MBS1231340 from MyBioSource Category Protein Prices $1,180.00, $1,180.00, $1,400.00, $1,400.00, $1,895.00, $1,895.00, $2,360.00, $2,360.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human GUCY2C Protein (24-430 aa), His-tagged - GUCY2C-2766H from Creative Biomart Category Protein Source Baculovirus Species Human

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