Gene Symbol | P2RY1 |
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Entrez Gene | 5028 |
Alt Symbol | P2Y1 |
Species | Human |
Gene Type | protein-coding |
Description | purinergic receptor P2Y, G-protein coupled, 1 |
Other Description | ATP receptor|P2 purinoceptor subtype Y1|P2Y purinoceptor 1|platelet ADP receptor |
Swissprots | P47900 |
Accessions | AAB47091 CAA07339 EAW78773 P47900 AF018284 AAB94556 AK313920 BAG36641 AY136752 AAN01278 BC074784 AAH74784 BC074785 AAH74785 U42029 AAA97872 U42030 AAA97873 Z49205 CAA89066 NM_002563 NP_002554 |
Function | Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. {ECO:0000269|PubMed:9442040}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Top Pathways | Rap1 signaling pathway, Neuroactive ligand-receptor interaction |
P2Y1 CRISPR/Cas9 KO Plasmid (h) - sc-401759 from Santa Cruz Biotechnology
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P2Y1 HDR Plasmid (h) - sc-401759-HDR from Santa Cruz Biotechnology
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P2Y1 Double Nickase Plasmid (h) - sc-401759-NIC from Santa Cruz Biotechnology
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P2Y1 Double Nickase Plasmid (h2) - sc-401759-NIC-2 from Santa Cruz Biotechnology
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P2Y1 CRISPR Activation Plasmid (h) - sc-401759-ACT from Santa Cruz Biotechnology
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P2Y1 CRISPR Activation Plasmid (h2) - sc-401759-ACT-2 from Santa Cruz Biotechnology
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P2Y1 Lentiviral Activation Particles (h) - sc-401759-LAC from Santa Cruz Biotechnology
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P2Y1 Lentiviral Activation Particles (h2) - sc-401759-LAC-2 from Santa Cruz Biotechnology
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P2Y1 siRNA (h) - sc-42577 from Santa Cruz Biotechnology
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P2Y1 shRNA Plasmid (h) - sc-42577-SH from Santa Cruz Biotechnology
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P2Y1 shRNA (h) Lentiviral Particles - sc-42577-V from Santa Cruz Biotechnology
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P2Y1/P2RY1 RNAi - H00005028-R02 from Novus Biologicals
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MISSION® esiRNA - EHU033811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16231 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08724 from Sigma-Aldrich
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P2RY1 siRNA (Human) - CRH3341 from Cohesion Biosciences
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P2Y1 CRISPR/Cas9 KO Plasmid (h2) - sc-401759-KO-2 from Santa Cruz Biotechnology
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P2Y1 HDR Plasmid (h2) - sc-401759-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human P2RY1 (NM_002563.3) - SHH369524 from Creative biogene
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Human P2RY1 siRNA - orb263843 from Biorbyt
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P2RY1 shRNA Plasmid (Human) - CHH3341 from Cohesion Biosciences
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P2RY1 miRNA 3'UTR clone - MiUTR3H-03925 from Creative biogene
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