| Gene Symbol |
ELOVL6
|
| Entrez Gene |
79071
|
| Alt Symbol |
FACE, FAE, LCE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ELOVL fatty acid elongase 6
|
| Other Description |
3-keto acyl-CoA synthase ELOVL6|ELOVL FA elongase 6|ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)|elongation of very long chain fatty acids protein 6|fatty acid elongase 2|fatty acyl-CoA elongase|hELO2|long-chain fatty-acyl elongase|very-long-chain 3-oxoacyl-CoA synthase 6
|
| Swissprots |
Q4W5L0 Q9H5J4 Q8NCD1
|
| Accessions |
AAY40928 EAX06258 EAX06259 EAX06260 Q9H5J4 AK027031 BAB15632 AK074813 BAC11225 AK074882 BC001305 AAH01305 BE539688 BP278053 BP314858 DB368351 H65618 XM_011532233 XP_011530535 XM_011532234 XP_011530536 XM_011532235 XP_011530537 NM_001130721 NP_001124193 NM_024090 NP_076995
|
| Function |
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:20937905}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:20937905}.
|
| Top Pathways |
Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism
|