ELOVL6

Gene Symbol ELOVL6
Entrez Gene 79071
Alt Symbol FACE, FAE, LCE
Species Human
Gene Type protein-coding
Description ELOVL fatty acid elongase 6
Other Description 3-keto acyl-CoA synthase ELOVL6|ELOVL FA elongase 6|ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)|elongation of very long chain fatty acids protein 6|fatty acid elongase 2|fatty acyl-CoA elongase|hELO2|long-chain fatty-acyl elongase|very-long-chain 3-oxoacyl-CoA synthase 6
Swissprots Q4W5L0 Q9H5J4 Q8NCD1
Accessions AAY40928 EAX06258 EAX06259 EAX06260 Q9H5J4 AK027031 BAB15632 AK074813 BAC11225 AK074882 BC001305 AAH01305 BE539688 BP278053 BP314858 DB368351 H65618 XM_011532233 XP_011530535 XM_011532234 XP_011530536 XM_011532235 XP_011530537 NM_001130721 NP_001124193 NM_024090 NP_076995
Function Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:20937905}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:20937905}.
Top Pathways Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism

ELOVL6 CRISPR/Cas9 KO Plasmid (h) - sc-413125 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL6 HDR Plasmid (h) - sc-413125-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL6 Double Nickase Plasmid (h) - sc-413125-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL6 Double Nickase Plasmid (h2) - sc-413125-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL6 CRISPR Activation Plasmid (h) - sc-413125-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL6 CRISPR Activation Plasmid (h2) - sc-413125-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL6 Lentiviral Activation Particles (h) - sc-413125-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL6 Lentiviral Activation Particles (h2) - sc-413125-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ELOVL6 siRNA (h) - sc-62271 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ELOVL6 shRNA Plasmid (h) - sc-62271-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ELOVL6 shRNA (h) Lentiviral Particles - sc-62271-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU005171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7825 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7825 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13190 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13190

ELOVL6 siRNA (Human) - CRJ2290 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ELOVL6 - MBS8234580 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ELOVL6 (NM_024090.2) - SHH285305 from Creative biogene

Category siRNA
Species Reactivities Human

Human ELOVL6 siRNA - orb272791 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ELOVL6 shRNA Plasmid (Human) - CHJ2290 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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